The Membrane Associated RING-CH Proteins: A Family of E3 Ligases with Diverse Roles through the Cell

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td align="left">Potential target of MARCH9</td><td align="left">Known function</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">PTPRA</td><td align="left">Receptor tyrosine phosphatase</td></tr><tr><td align="left">PTPRJ (CD148)</td><td align="left">Receptor tyrosine phosphatase</td></tr><tr><td align="left">PTPRF</td><td align="left">Receptor tyrosine phosphatase</td></tr><tr><td align="left">HLA-DQA</td><td align="left">Present of processed antigens to T cells</td></tr><tr><td align="left">HLA-DQB</td><td align="left">Present of processed antigens to T cells </td></tr><tr><td align="left">SLAM (CD150)</td><td align="left">A self-ligand costimulatory receptor <br/>Receptor that recognizes Gram-negative bacteria <br/>Regulates the macrophage-killing machinery in phagosomes</td></tr><tr><td align="left">ILT-2 (CD85j/LIR-1/LILRB1)</td><td align="left">NK cell inhibitory receptor</td></tr><tr><td align="left">FCRL2</td><td align="left">Fc receptor related molecule</td></tr><tr><td align="left">Plexin C1 (CD232)</td><td align="left">Inhibitor of integrin-mediated adhesion of DCs</td></tr><tr><td align="left">VAMP8</td><td align="left">SNARE involved in endocytic vesicle fusion</td></tr><tr><td align="left">TMEM2</td><td align="left">Involved in myocardial and endocardial morphogenesis</td></tr><tr><td align="left">TRAIL-R1</td><td align="left">Immune surveillance</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

List of potential targets of MARCH9 identified in a SILAC experiment.

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Table 1: The Membrane Associated RING-CH Proteins: A Family of E3 Ligases with Diverse Roles through the Cell 