Research Article
Synthesis and Biological Activities of 4-Aminoantipyrine Derivatives Derived from Betti-Type Reaction
Table 1
Results of anti-inflammatory activity of 4-aminoantipyrine derivatives 4(a–h).
| Test Compds | Increase in paw volume at different time interval (h)a |
% inhibition | 150 mg/kg | 0 | 1 | 2 | 3 | 4 |
| Control | 0.32 ± 0.03 | 0.58 ± 0.02 | 0.83 ± 0.05 | 1.96 ± 0.01* | 2.15 ± 0.04 | — | 4a | 0.33 ± 0.02* | 0.59 ± 0.01 | 0.80 ± 0.05* | 0.78 ± 0.03 | 0.74 ± 0.01 | 47.27 | 4b | 0.33 ± 0.05 | 0.56 ± 0.02 | 0.78 ± 0.03 | 0.77 ± 0.03 | 0.71 ± 0.03* | 49.10 | 4c | 0.30 ± 0.04* | 0.47 ± 0.03 | 0.49 ± 0.02 | 0.34 ± 0.05* | 0.33 ± 0.02 | 78.91 | 4d | 0.31 ± 0.02* | 0.47 ± 0.04 | 0.45 ± 0.01 | 0.37 ± 0.02 | 0.31 ± 0.03 | 74.82 | 4e | 0.31 ± 0.05 | 0.42 ± 0.01* | 0.46 ± 0.03 | 0.34 ± 0.02 | 0.32 ± 0.03* | 72.73 | 4f | 0.30 ± 0.04* | 0.36 ± 0.04 | 0.42 ± 0.05 | 0.33 ± 0.01* | 0.31 ± 0.04 | 74.55 | 4g | 0.32 ± 0.05 | 0.54 ± 0.03* | 0.66 ± 0.02* | 0.49 ± 0.04 | 0.44 ± 0.01* | 61.82 | 4h | 0.30 ± 0.03 | 0.34 ± 0.01* | 0.41 ± 0.05* | 0.33 ± 0.04 | 0.31 ± 0.05* | 76.45 | Diclofenac (10 mg/kg) | 0.30 ± 0.01 | 0.31 ± 0.03 | 0.33 ± 0.05* | 0.12 ± 0.04 | 0.10 ± 0.02* | 80.45 |
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Significantly different from control at .
aResults are expressed as mean ± SEM.
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