International Scholarly Research Notices / 2014 / Article / Tab 1

Research Article

Synthesis and Biological Activities of 4-Aminoantipyrine Derivatives Derived from Betti-Type Reaction

Table 1

Results of anti-inflammatory activity of 4-aminoantipyrine derivatives 4(a–h).

Test CompdsIncrease in paw volume at different time interval (h)a % inhibition
150 mg/kg
01234

Control0.32 ± 0.030.58 ± 0.020.83 ± 0.051.96 ± 0.01*2.15 ± 0.04
4a0.33 ± 0.02*0.59 ± 0.010.80 ± 0.05*0.78 ± 0.030.74 ± 0.0147.27
4b0.33 ± 0.050.56 ± 0.020.78 ± 0.030.77 ± 0.030.71 ± 0.03*49.10
4c0.30 ± 0.04*0.47 ± 0.030.49 ± 0.020.34 ± 0.05*0.33 ± 0.0278.91
4d0.31 ± 0.02*0.47 ± 0.040.45 ± 0.010.37 ± 0.020.31 ± 0.0374.82
4e0.31 ± 0.050.42 ± 0.01*0.46 ± 0.030.34 ± 0.020.32 ± 0.03*72.73
4f0.30 ± 0.04*0.36 ± 0.040.42 ± 0.050.33 ± 0.01*0.31 ± 0.0474.55
4g0.32 ± 0.050.54 ± 0.03*0.66 ± 0.02*0.49 ± 0.040.44 ± 0.01*61.82
4h0.30 ± 0.030.34 ± 0.01*0.41 ± 0.05*0.33 ± 0.040.31 ± 0.05*76.45
Diclofenac (10 mg/kg)0.30 ± 0.010.31 ± 0.030.33 ± 0.05*0.12 ± 0.040.10 ± 0.02*80.45

Significantly different from control at .
aResults are expressed as mean ± SEM.