Research Article
Synthesis and Biological Activities of 4-Aminoantipyrine Derivatives Derived from Betti-Type Reaction
Table 3
Molinspiration calculation of 4-aminoantipyrine derivatives 4(a–h).
| Compounds | MW | mi log | TPSA | OH-HN | N violation | Volume |
| 4a | 481 | 3.98 | 117 | 2 | 0 | 421 | 4b | 481 | 3.96 | 117 | 2 | 0 | 421 | 4c | 466 | 4.10 | 81 | 2 | 0 | 423 | 4d | 479 | 4.12 | 75 | 2 | 0 | 444 | 4e | 452 | 3.57 | 92 | 3 | 0 | 406 | 4f | 452 | 3.99 | 92 | 3 | 0 | 406 | 4g | 470 | 4.72 | 72 | 2 | 0 | 411 | 4h | 470 | 4.68 | 72 | 2 | 0 | 411 | Diclofenac | 296 | 4.56 | 49 | 2 | 0 | 238 | Albendazole | 265 | 2.74 | 67 | 2 | 0 | 234 |
|
|
MW: molecular weight; TPSA: Topological polar surface area.
|