Table of Contents
ISRN Pathology
Volume 2014 (2014), Article ID 640829, 8 pages
http://dx.doi.org/10.1155/2014/640829
Review Article

Do Foxp3+ Regulatory T Cells (Treg Cells) Play a Role in the Immunopathogenesis of Primary/Idiopathic Minimal Change Disease?

1Tregs and HLA Research Force and Department of Pathology, Singapore General Hospital, The Academia, 20 College Road, Singapore 169856
2Renal Medicine Department, Singapore General Hospital, The Academia, 20 College Road, Singapore 169856
3Tregs and HLA Research Force and Renal Medicine Department, Singapore General Hospital, The Academia, Level 3, 20 College Road, Singapore 169856
4Department of Pathology, Singapore General Hospital, The Academia, 20 College Road, Singapore 169856

Received 26 September 2013; Accepted 6 January 2014; Published 19 February 2014

Academic Editors: K. Honda, A. Satoskar, M. Schaller, and M. Urushihara

Copyright © 2014 Susan Swee-Shan Hue et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Barisoni, H. W. Schnaper, and J. B. Kopp, “A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseases,” Clinical Journal of the American Society of Nephrology, vol. 2, no. 3, pp. 529–542, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. R. J. Shalhoub, “Pathogenesis of lipoid nephrosis: a disorder of T cell function,” The Lancet, vol. 2, no. 7880, pp. 556–560, 1974. View at Google Scholar · View at Scopus
  3. S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, and M. Toda, “Immunologic self-tolerance maintained by activated T cells expressing IL- 2 receptor α-chains (CD25): breakdown of a single mechanism of self- tolerance causes various autoimmune diseases,” Journal of Immunology, vol. 155, no. 3, pp. 1151–1164, 1995. View at Google Scholar · View at Scopus
  4. S. Sakaguchi, T. Yamaguchi, T. Nomura, and M. Ono, “Regulatory T cells and immune tolerance,” Cell, vol. 133, no. 5, pp. 775–787, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. C. L. Bennett, J. Christie, F. Ramsdell et al., “The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3,” Nature Genetics, vol. 27, no. 1, pp. 20–21, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Benz, M. Büttner, K. Dittrich, V. Campean, J. Dötsch, and K. Amann, “Characterisation of renal immune cell infiltrates in children with nephrotic syndrome,” Pediatric Nephrology, vol. 25, no. 7, pp. 1291–1298, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Bertelli, M. Bodria, M. Nobile et al., “Regulation of innate immunity by the nucleotide pathway in children with idiopathic nephrotic syndrome,” Clinical and Experimental Immunology, vol. 166, no. 1, pp. 55–63, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. C. Araya, L. Diaz, C. Wasserfall et al., “T regulatory cell function in idiopathic minimal lesion nephrotic syndrome,” Pediatric Nephrology, vol. 24, no. 9, pp. 1691–1698, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. L.-L. Liu, Y. Qin, J.-F. Cai et al., “Th17/Treg imbalance in adult patients with minimal change nephrotic syndrome,” Clinical Immunology, vol. 139, no. 3, pp. 314–320, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. X. S. Shao, X. Q. Yang, X. D. Zhao et al., “The prevalence of Th17 cells and FOXP3 regulate T cells (Treg) in children with primary nephrotic syndrome,” Pediatric Nephrology, vol. 24, no. 9, pp. 1683–1690, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Hashimura, K. Nozu, H. Kanegane et al., “Minimal change nephrotic syndrome associated with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome,” Pediatric Nephrology, vol. 24, no. 6, pp. 1181–1186, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Miyara, Y. Yoshioka, A. Kitoh et al., “Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor,” Immunity, vol. 30, no. 6, pp. 899–911, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. D. J. Campbell and M. A. Koch, “Phenotypical and functional specialization of FOXP3+ regulatory T cells,” Nature Reviews Immunology, vol. 11, no. 2, pp. 119–130, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Ding, J. Xu, and J. S. Bromberg, “Regulatory T cell migration during an immune response,” Trends in Immunology, vol. 33, no. 4, pp. 174–179, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Liu, P. Zhang, J. Li, A. B. Kulkarni, S. Perruche, and W. Chen, “A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells,” Nature Immunology, vol. 9, no. 6, pp. 632–640, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. J. L. Bautista, C.-W. J. Lio, S. K. Lathrop et al., “Intraclonal competition limits the fate determination of regulatory T cells in the thymus,” Nature Immunology, vol. 10, no. 6, pp. 610–617, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Huehn, K. Siegmund, J. C. U. Lehmann et al., “Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells,” The Journal of Experimental Medicine, vol. 199, no. 3, pp. 303–313, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. C. Benoist and D. Mathis, “Treg cells, life history, and diversity,” Cold Spring Harbor Perspectives in Biology, vol. 4, no. 9, Article ID a007021, 2012. View at Publisher · View at Google Scholar
  19. J. A. Bluestone and H. Bour-Jordan, “Current and future immunomodulation strategies to restore tolerance in autoimmune diseases,” Cold Spring Harbor Perspectives in Biology, vol. 4, no. 11, Article ID a007542, 2012. View at Publisher · View at Google Scholar
  20. W. Chen, W. Jin, N. Hardegen et al., “Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3,” The Journal of Experimental Medicine, vol. 198, no. 12, pp. 1875–1886, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. I. Apostolou and H. von Boehmer, “In vivo instruction of suppressor commitment in naive T cells,” The Journal of Experimental Medicine, vol. 199, no. 10, pp. 1401–1408, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. M. A. Curotto de Lafaille, N. Kutchukhidze, S. Shen, Y. Ding, H. Yee, and J. J. Lafaille, “Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation,” Immunity, vol. 29, no. 1, pp. 114–126, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Kleinewietfeld, F. Puentes, G. Borsellino, L. Battistini, O. Rötzschke, and K. Falk, “CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T-cell subset,” Blood, vol. 105, no. 7, pp. 2877–2886, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Deaglio, K. M. Dwyer, W. Gao et al., “Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression,” The Journal of Experimental Medicine, vol. 204, no. 6, pp. 1257–1265, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. G. Borsellino, M. Kleinewietfeld, D. di Mitri et al., “Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression,” Blood, vol. 110, no. 4, pp. 1225–1232, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. F. Salcido-Ochoa, J. Tsang, P. Tam, K. Falk, and O. Rotzschke, “Regulatory T cells in transplantation: does extracellular adenosine triphosphate metabolism through CD39 play a crucial role?” Transplantation Reviews, vol. 24, no. 2, pp. 52–66, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. A. M. Thornton and E. M. Shevach, “Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific,” Journal of Immunology, vol. 164, no. 1, pp. 183–190, 2000. View at Google Scholar · View at Scopus
  28. E. M. Shevach, “Mechanisms of Foxp3+ T regulatory cell-mediated suppression,” Immunity, vol. 30, no. 5, pp. 636–645, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. E. Schnenberger, J. H. Ehrich, H. Haller, and M. Schiffer, “The podocyte as a direct target of immunosuppressive agents,” Nephrology Dialysis Transplantation, vol. 26, no. 1, pp. 18–24, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. J. G. van den Berg, J. Aten, M. A. Chand et al., “Interleukin-4 and interleukin-13 act on glomerular visceral epithelial cells,” Journal of the American Society of Nephrology, vol. 11, no. 3, pp. 413–422, 2000. View at Google Scholar · View at Scopus
  31. E. H. Garin, P. F. Laflam, and K. Muffly, “Proteinuria and fusion of podocyte foot processes in rats after infusion of cytokine from patients with idiopathic minimal lesion nephrotic syndrome,” Nephron Experimental Nephrology, vol. 102, no. 3-4, pp. e105–e112, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Shimada, C. Araya, C. Rivard, T. Ishimoto, R. J. Johnson, and E. H. Garin, “Minimal change disease: a “two-hit” podocyte immune disorder?” Pediatric Nephrology, vol. 26, no. 4, pp. 645–649, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. C. Gluhovschi, G. Gluhovschi, E. Potencz et al., “What is the significance of HLA-DR antigen expression in the extraglomerular mesangium in glomerulonephritis?” Human Immunology, vol. 73, no. 11, pp. 1098–1101, 2012. View at Publisher · View at Google Scholar
  34. E. H. Garin, W. Mu, J. M. Arthur et al., “Urinary CD80 is elevated in minimal change disease but not in focal segmental glomerulosclerosis,” Kidney International, vol. 78, no. 3, pp. 296–302, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. E. H. Garin, L. N. Diaz, W. Mu et al., “Urinary CD80 excretion increases in idiopathic minimal-change disease,” Journal of the American Society of Nephrology, vol. 20, no. 2, pp. 260–266, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. T. Ishimoto, G. Cara-Fuentes, H. Wang et al., “Serum from minimal change patients in relapse increases CD80 expression in cultured podocytes,” Pediatric Nephrology, vol. 28, no. 9, pp. 1803–1812, 2013. View at Publisher · View at Google Scholar
  37. S. Read, V. Malmström, and F. Powrie, “Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+CD4+ regulatory cells that control intestinal inflammation,” The Journal of Experimental Medicine, vol. 192, no. 2, pp. 295–302, 2000. View at Publisher · View at Google Scholar · View at Scopus
  38. K. Wing, Y. Onishi, P. Prieto-Martin et al., “CTLA-4 control over Foxp3+ regulatory T cell function,” Science, vol. 322, no. 5899, pp. 271–275, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. D. S. Segundo, J. C. Ruiz, M. Izquierdo et al., “Calcineurin inhibitors, but not rapamycin, reduce percentages of CD4+CD25+FOXP3+ regulatory T cells in renal transplant recipients,” Transplantation, vol. 82, no. 4, pp. 550–557, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. G. Andreola, M. Chittenden, J. Shaffer et al., “Mechanisms of donor-specific tolerance in recipients of haploidentical combined bone marrow/kidney transplantation,” American Journal of Transplantation, vol. 11, no. 6, pp. 1236–1247, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. S. Shibutani, F. Inoue, O. Aramaki et al., “Effects of immunosuppressants on induction of regulatory cells after intratracheal delivery of alloantigen,” Transplantation, vol. 79, no. 8, pp. 904–913, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. J. H. L. Velthuis, W. M. Mol, W. Weimar, and C. C. Baan, “CD4+ CD25bright+ regulatory T cells can mediate donor nonreactivity in long-term immunosuppressed kidney allograft patients,” American Journal of Transplantation, vol. 6, no. 12, pp. 2955–2964, 2006. View at Publisher · View at Google Scholar · View at Scopus