Table of Contents
International Scholarly Research Notices
Volume 2014 (2014), Article ID 659410, 13 pages
http://dx.doi.org/10.1155/2014/659410
Clinical Study

Effects of a Comprehensive, Intensive Lifestyle Intervention Combined with Metformin Extended Release in Obese Adolescents

1Children’s Hospital, London Health Sciences Centre, P.O. Box 5010, London, ON, Canada N6A 5W9
2Lawson Health Research Institute, University of Western Ontario, London, ON, Canada N6A 5A5
3Department of Paediatrics, University of Western Ontario, London, ON, Canada N6A 5A5
4Department of Epidemiology & Biostatistics, University of Western Ontario, London, ON, Canada N6A 5A5
5School of Kinesiology, University of Western Ontario, London, ON, Canada N6A 5A5
6Department of Medicine, University of Western Ontario, London, ON, Canada N6A 5A5
7Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada N6A 5A5

Received 1 August 2014; Revised 23 September 2014; Accepted 25 September 2014; Published 10 November 2014

Academic Editor: Cheryl A. Gibson

Copyright © 2014 Cheril L. Clarson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To assess a comprehensive, intensive lifestyle intervention in combination with metformin extended release (MXR) or placebo on body mass index (BMI) and risk factors for type 2 diabetes and cardiovascular disease in obese adolescents. Study Design. Sixty-nineobese adolescents (mean BMI 32.5) received a comprehensive lifestyle intervention with structured dietary, physical activity, and behavioral components for 24 months. Subjects were randomized to 1 of 4 groups: MXR (33) 2,000 mg daily or placebo, with either moderate or vigorous intensity exercise for the first 3 months. Subsequently the exercise intervention was the same for all 4 groups. Results. Anthropometry measurements did not differ with initial exercise intensity at any time. At 3 months % body fat decreased in all 4 groups (). BMI and % body fat decreased in the MXR groups, but not the placebo groups, at 6 (−0.88, −3.16) and 12 months (−0.56, −2.34) (). Insulin resistance, fasting blood glucose, and leptin improved in all groups at 6 and 12 months. A high subject attrition rate (58%) occurred by 24 months. Conclusion. A comprehensive, intensive lifestyle intervention combined with MXR led to a decline in BMI and % body fat at 1 year independent of initial exercise intensity. This trial is registered with ClinicalTrials.gov NCT00934570 .