Emergence of Drug Resistance in Human Immunodeficiency Virus Type 1 Infected Patients from Pune, India, at the End of 12 Months of First Line Antiretroviral Therapy Initiation

Table 1

Details of GenBank accession number, first line ART regimen, CD4⁺ T-cell counts, HIV-1 RNA level, and HIVDR mutations of 19 plasma specimens with HIV-1 RNA level > 1000 copies/mL.

Serial number	GenBank accession; number	ART Combination	CD4^+ T-cell counts (cells/𝜇L) after 12 months; of ART initiation	HIV-1; RNA level (copies/mL) after 12 months of ART initiation	HIVDR mutations
					NRTI mutations	NNRTI mutations
1	HQ456679	3TC, AZT, NVP	312	9,63,000	M41L, M184V, T215Y, N348I	Y188L
2	HQ456669	3TC, AZT, NVP, EFZ	184	83,635	D67N, T69ADNT, K70R, M184V, T215F, K219Q	K103N, Y188, M230L
3	HQ456677	3TC, AZT, NVP, EFZ	95	33,668	D67N, K70R, M184V, T215F, K219EKQ	K103N, P225H,; K238T
4	HQ456671	3TC, AZT, NVP, D4T	224	22,034	M184MV	K103N
5	HQ456667	3TC, AZT, NVP	<50	13,491	M41L, E44D, D67N, M184V, L210LS, T215Y	A98G, K101Q,; Y181C
6	HQ456681	3TC, AZT, NVP, EFZ	240	7,421	M184V	K103N
7	HQ456680	3TC, AZT, EFZ	290	7,310	None	K103N,; V106MV
8	HQ456672	D4T, 3TC, NVP	375	2,604	L74LV, M184V	K103S, M23OL, K238N
9	HQ456675	D4T, 3TC, NVP	275	1,397	M184V	G190A
10	HQ456668	3TC, AZT, NVP	368	1,335	M184V	K103N
11	HQ456673	3TC, AZT, NVP	143	4,12,721	None	None
12	HQ456678	3TC, AZT, NVP	280	58,243	None	None
13	HQ456674	3TC, AZT, NVP	264	39,916	None	None
14	HQ456676	3TC, AZT, NVP	278	2,526	None	None
15	HQ456670	D4T, 3TC, NVP	254	2,032	None	None
16	HQ456682	3TC, AZT, NVP	370	1,614	None	None
17	—	3TC, AZT, NVP	113	3,69,247	No amplification
18	—	3TC, AZT, NVP,; EFZ, D4T	390	2,030	No amplification
19	—	3TC, AZT, NVP	240	1,026	No amplification