Table of Contents
International Scholarly Research Notices
Volume 2014, Article ID 687697, 5 pages
Research Article

The Study of Analgesic Effects of Leonurus cardiaca L. in Mice by Formalin, Tail Flick and Hot Plate Tests

1Department of Pharmacology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
2Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran 1417613151, Iran

Received 22 April 2014; Accepted 19 June 2014; Published 1 September 2014

Academic Editor: Yeong-Ray Wen

Copyright © 2014 Masoume Rezaee-Asl et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Leonurus cardiaca, commonly known as motherwort, is a member of the Lamiaceae family. It has a number of interesting biological activities, for example, sedative and hypotensive, antioxidant, anti-inflammatory, and antimicrobial activities. The aim of the present study was to investigate the effect of alcoholic extract of aerial part of Leonurus cardiaca on nociceptive response using formalin, tail flick, and hot plate tests in mice. The acute treatment of mice with an ethanolic extract at doses of 500 and 250 mg/kg by intraperitoneal administration produced a significant antinociceptive in the first and second phases of formalin test, respectively. The hot plate and tail flick tests showed an increase in the antinociceptive effect at dose 500 mg/kg. These results suggest that Leonurus cardiaca possesses central and peripheral antinociceptive actions.