Table of Contents
ISRN Microbiology
Volume 2014 (2014), Article ID 715310, 3 pages
http://dx.doi.org/10.1155/2014/715310
Research Article

Emergence of blaTEM Type Extended-Spectrum β-Lactamase Producing Salmonella spp. in the Urban Area of Bangladesh

International Centre for Diarrheal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh

Received 23 January 2014; Accepted 25 February 2014; Published 10 March 2014

Academic Editors: G. Koraimann and F. Navarro-Garcia

Copyright © 2014 Dilruba Ahmed et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Salmonellosis, an acute invasive enteric infection, is endemic in Bangladesh. We analyzed 128,312 stool samples of diarrheal patients to identify Salmonella spp. during 2005–2013. A total of 2120 (1.7%) Salmonella spp. were isolated and the prevalence of Salmonella spp. decreased significantly over time (2→1%, ). Among the typhoidal Salmonella (TS) serogroups, S. Typhi was predominant (404, [65.1%]) followed by S. Paratyphi B (139, [22.4%]) and S. Paratyphi A (78, [12.6%]). Of the nontyphoidal Salmonella (NTS) isolates, the serogroup C1 (560, [37%]) was predominant followed by B (379, [25%]), C2 (203, [14%]), E (127, [9%]), and D (94, [6%]). Most of the resistance was found towards nalidixic acid (40%), ampicillin (36%), cotrimoxazole (20%), chloramphenicol (13%), ciprofloxacin (4%), and ceftriaxone (4%). Interestingly, 32% of the isolates showed reduced susceptibility to Cip. Multiantibiotic resistance (MAR, ≥3 drugs) was more common among TS than NTS strains ( ). Among the representative ceftriaxone-resistant isolates, gene was detected among 88% (7/8) of the strains, whereas only one strain of S. Typhi was positive for both and genes. The study reflects higher prevalence of MAR Salmonella spp. and is the first to report the gene mediated ESBL production among Salmonellae in Bangladesh. Emergence of MAR Salmonella spp. in particular ESBL strains should be considered a public health concern.