Table of Contents
ISRN Biomaterials
Volume 2014, Article ID 718432, 8 pages
Research Article

Reducing the Foreign Body Reaction by Surface Modification with Collagen/Hyaluronic Acid Multilayered Films

1Department of Chemical Engineering, National Taiwan University, Taipei 106, Taiwan
2Department of Physical Medicine and Rehabilitation of National Taiwan University Hospital, Taipei 100, Taiwan

Received 3 December 2013; Accepted 6 January 2014; Published 13 April 2014

Academic Editors: S. Lamponi, S. Liao, and J. Wang

Copyright © 2014 Cindy Yi Chi Hsieh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Biological response against foreign implants often leads to encapsulation, possibly resulting in malfunction of implants devices. The aim of this study was to reduce the foreign body reaction by surface modification of biomaterials through layer-by-layer deposition of type I collagen (COL)/hyaluronic acid (HA) multilayer films. Polydimethylsiloxane (PDMS) samples were coated with alternative COL and HA layers with different layers. We found that the in vitro adhesion, proliferation, and activation of macrophage-like cells were greatly decreased by COL/HA multilayered deposition. The PDMS samples modified with 20 bilayers of COL/HA were implanted in rats for 3 weeks, and the thickness of encapsulation surrounding the samples was decreased by 29–57% compared to the control unmodified PDMS. This study demonstrates the potential of COL/HA multilayer films to reduce foreign body reaction.