Table of Contents
International Scholarly Research Notices
Volume 2014 (2014), Article ID 738493, 9 pages
http://dx.doi.org/10.1155/2014/738493
Research Article

Investigation of Pharmacological Activity of Caralluma penicillata: Anti-Inflammatory Properties and Gastritis Protection against Indomethacin in Adult Guinea Pigs

1Department of Pharmacology and Therapeutic, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen
2Tihama Foundation for Drug Studies and Research, Hodeidah, Yemen
3Department of Pharmacy Practice, Faculty of Clinical Pharmacy, Hodeidah University, P.O. Box 3114, Hodeidah, Yemen

Received 17 July 2014; Accepted 15 October 2014; Published 4 December 2014

Academic Editor: Carmela Saturnino

Copyright © 2014 Nabil Albaser et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Bader, A. Braca, N. de Tommasi, and I. Morelli, “Further constituents from Caralluma negevensis,” Phytochemistry, vol. 62, no. 8, pp. 1277–1281, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Venkatesh, G. D. Reddy, B. M. Reddy, M. Ramesh, and A. V. N. A. Rao, “Antihyperglycemic activity of Caralluma attenuata,” Fitoterapia, vol. 74, no. 3, pp. 274–279, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. M. D. Al-Harbi, S. Qureshi, M. Raza, M. M. Ahmed, M. Afzal, and A. H. Shah, “Evaluation of Caralluma tuberculafa pretreatment for the protection of rat gastric mucosa against toxic damage,” Toxicology and Applied Pharmacology, vol. 128, no. 1, pp. 1–8, 1994. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Deepak, A. Khare, and M. P. Khare, “Plant pregnanes,” Phytochemistry, vol. 28, no. 12, pp. 3255–3263, 1989. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Deepak, S. Srivastav, and A. Khare, “Pregnane glycosides,” Progress in the Chemistry of Organic Natural Products, vol. 71, pp. 169–325, 1997. View at Google Scholar
  6. M. N. M. Zakaria, M. W. Islam, R. Radhakrishnan et al., “Anti-nociceptive and anti-inflammatory properties of Caralluma arabica,” Journal of Ethnopharmacology, vol. 76, no. 2, pp. 155–158, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Ramesh, Y. N. Rao, M. R. Kumar et al., “Flavone glycoside from three Caralluma species,” Biochemical Systematics and Ecology, vol. 27, no. 1, pp. 85–86, 1999. View at Publisher · View at Google Scholar · View at Scopus
  8. M. A. Al-Yahya, M. Tariq, T. I. Khalifa, and I. Ashraf, “Toxicity studies on Caralluma penicillata—a poisonous plant from Saudi Arabia,” Toxicon, vol. 21, no. 3, pp. 9–12, 1983. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Venkatesh, G. D. Reddy, B. M. Reddy, M. Ramesh, and A. V. N. A. Rao, “Antihyperglycemic activity of Caralluma attenuata,” Fitoterapia, vol. 74, no. 3, pp. 274–279, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. L.-J. Lin, L.-Z. Lin, R. R. Gil et al., “Pregnane glycosides from Caralluma Umbellata,” Phytochemistry, vol. 35, no. 6, pp. 1549–1553, 1994. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Braca, A. Bader, I. Morelli et al., “New pregnane glycosides from Caralluma negevensis,” Tetrahedron, vol. 58, no. 29, pp. 5837–5848, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. M. M. Ahmed, S. Qureshi, A. M. Al-Bekairi, A. H. Shah, R. M. Rao, and N. S. Qazi, “Anti-inflammatory activity of Caralluma tuberculata alcoholic extract,” Fitoterapia, vol. 64, no. 4, pp. 357–360, 1993. View at Google Scholar · View at Scopus
  13. E. Abdel-Sattar, M. A.-A. Al-Yahya, N. Nakamura, and M. Hattori, “Penicillosides A-C, C-15 oxypregnane glycosides from Caralluma penicillata,” Phytochemistry, vol. 57, no. 8, pp. 1213–1217, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. E. Abdel-Sattar, M. R. Meselhy, and M. A. A. Al-Yahya, “New oxypregnane glycosides from Caralluma penicillata,” Planta Medica, vol. 68, no. 5, pp. 430–434, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Panthong, D. Kanjanapothi, Y. Thitiponpunt, T. Taesotikul, and D. Arbain, “Anti-inflammatory activity of the alkaloid bukittinggine from Sapium baccatum,” Planta Medica, vol. 64, no. 6, pp. 530–535, 1998. View at Publisher · View at Google Scholar · View at Scopus
  16. C. A. Winter, E. A. Risely, and G. W. Nuss, “Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs,” Proceedings of the Society for Experimental Biology and Medicine, vol. 111, pp. 544–547, 1962. View at Publisher · View at Google Scholar · View at Scopus
  17. P. A. Akah and A. I. Nwambie, “Evaluation of Nigerian traditional medicines: 1. Plants used for rheumatic (inflammatory) disorders,” Journal of Ethnopharmacology, vol. 42, no. 3, pp. 179–182, 1994. View at Publisher · View at Google Scholar · View at Scopus
  18. D. Chu and B. A. Kovacs, “Anti-inflammatory activity in oak gall extracts,” Archives Internationales de Pharmacodynamie et de Therapie, vol. 230, no. 1, pp. 166–176, 1977. View at Google Scholar · View at Scopus
  19. F. T. Fischbach and B. Marshall, A Manual of Laboratory Diagnostic Tests, J. B. Lippincott, Philadelphia, Pa, USA, 8th edition, 2008.
  20. R. Meier, W. Schuler, and P. Desaulles, “Zur Frage des Mechanismus der Hemmung des Bindegewebswachstums durch Cortisone,” Experientia, vol. 6, no. 12, pp. 469–471, 1950. View at Publisher · View at Google Scholar · View at Scopus
  21. U. K. Sheth, N. K. Dadkar, and U. K. Kama, Selected Topics in Experimental Pharmacology, The Kothari Book Depot, Bombay, India, 1st edition, 1972.
  22. A. D. Sedgwick and D. A. Willoughby, “Animal models for testing drugs on inflammatory and hypersensitivity reactions,” in Textbook of Immunopharmacology, Blackwell Scientific Publication, London, UK, 2nd edition, 1989. View at Google Scholar
  23. C. A. Hiruma-Lima, R. C. Spadari-Bratfisch, D. M. Grassi-Kassisse, and A. R. M. Souza Brito, “Antiulcerogenic mechanisms of dehydrocrotonin, a diterpene lactone obtained from Croton cajucara,” Planta Medica, vol. 65, no. 4, pp. 325–330, 1999. View at Publisher · View at Google Scholar · View at Scopus
  24. K. F. Swingle and F. E. Shideman, “Phases of the inflammatory response to subcutaneous implantation of a cotton pellet and their modification by certain anti-inflammatory agents,” Journal of Pharmacology and Experimental Therapeutics, vol. 183, no. 1, pp. 226–234, 1972. View at Google Scholar · View at Scopus
  25. S. Maity, T. Chaudhuri, J. R. Vedasiromoni, and D. K. Ganguly, “Cytoprotection mediated antiulcer effect of tea root extract,” Indian Journal of Pharmacology, vol. 35, no. 4, pp. 213–219, 2003. View at Google Scholar · View at Scopus
  26. R. A. B. Drury, E. A. Wallington, and R. Cameron, Carleton's Histological Techniques, Oxford University Press, New York, NY, USA, 4th edition, 1967.
  27. V. Kumar, K. Abul Abbas, and C. Jon Aster, Robbins Basic Pathology, Saunders, Philadelphia, Pa, USA, 8th edition, 2008.
  28. J. M. Anderson, “Biological responses to materials,” Annual Review of Materials Research, vol. 31, pp. 81–110, 2001. View at Publisher · View at Google Scholar
  29. P. Davies, P. J. Bailey, M. M. Goldenberg, and A. W. Ford-Hutchinson, “The role of arachidonic acid oxygenation products in pain and inflammation,” Annual Review of Immunology, vol. 2, pp. 335–357, 1984. View at Publisher · View at Google Scholar · View at Scopus
  30. S.-X. Qiu, G. A. Cordell, B. R. Kumar et al., “Bisdesmosidic pregnane glycosides from Caralluma lasiantha,” Phytochemistry, vol. 50, no. 3, pp. 485–491, 1999. View at Google Scholar
  31. M. Ramesh, Y. Nageshwar Rao, A. V. N. Appa Rao et al., “Antinociceptive and anti-inflammatory activity of a flavonoid isolated from Caralluma attenuata,” Journal of Ethnopharmacology, vol. 62, no. 1, pp. 63–66, 1998. View at Publisher · View at Google Scholar · View at Scopus
  32. N. M. Ansari, L. Houlihan, B. Hussain, and A. Pieroni, “Antioxidant activity of five vegetables traditionally consumed by South-Asian migrants in Bradford, Yorkshire, UK,” Phytotherapy Research, vol. 19, no. 10, pp. 907–911, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. D. E. Furst and T. Munster, Non-Steroidal Anti-Inflammatory Drugs, Basic and Clinical Pharmacology, Lange Medical Book/McGraw Hill Medical Publishing Division, 8th edition, 2001.
  34. N. H. G. Holford and L. Z. Benet, Pharmacokinetics and Pharmacodynamics: Dose Selection and the Time Course of Drug Action, Basic and Clinical Pharmacology, Appleton-Lange, 2001.
  35. M. Moulin and A. Coquerel, Pharmacologie, Connaissance et Pratique III MASSON, 2nd edition, 2000.