Investigation of Pharmacological Activity of Caralluma penicillata: Anti-Inflammatory Properties and Gastritis Protection against Indomethacin in Adult Guinea Pigs
Table 1
The anti-inflammatory effect of single intragastric administration of different doses of C. penicillata on fresh egg albumen (0.5 mL/kg) induced paw oedema in adult male guinea pigs ( = 6) to find out the effective dose for further use in experimental studies.
Groups
Original paw volume
Average volume of paw (M ± SE) paw volume (cubic centimeter)
30 min
60 min
90 min
120 min
150 min
180 min
Nontreated control Difference of paw volume (cc)
3.15 ± 0.10
3.82 ± 0.13*
3.95 ± 0.13*
4.35 ± 0.14*
4.0 ± 0.16*
3.9 ± 0.15*
3.57 ± 0.14*
0.7 ± 0.04
0.80 ± 0.04
1.2 ± 0.03
0.85 ± 0.05
0.75 ± 0.04
0.42 ± 0.03
C. penicillata (200 mg/kg) Difference of paw volume (cc)
3.08 ± 0.07
3.53 ± 0.09*
3.78 ± 0.09*
3.9 ± 0.10*
3.75 ± 0.10*
3.57 ± 0.09*
3.47 ± 0.09*
0.45 ± 0.03+
0.70 ± 0.02+
0.82 ± 0.03+
0.67 ± 0.04+
0.49 ± 0.05+
0.39 ± 0.03+
C. penicillata (400 mg/kg) Difference of paw volume (cc)
3.15 ± 0.10
3.57 ± 0.11*
3.67 ± 0.09*
3.65 ± 0.10*
3.57 ± 0.11*
3.47 ± 0.11*
3.42 ± 0.09*
0.42 ± 0.03+
0.52 ± 0.04+
0.50 ± 0.05+
0.42 ± 0.03+
0.32 ± 0.03+
0.27 ± 0.03+
C. penicillata (600 mg/kg) Difference of paw volume (cc)
3.0 ± 0.08
3.40 ± 0.06*
3.52 ± 0.11*
3.53 ± 0.11*
3.33 ± 0.16*
3.32 ± 0.11*
3.25 ± 0.05*
0.40 ± 0.02+
0.52 ± 0.03+
0.53 ± 0.03+
0.33 ± 0.02+
0.32 ± 0.02+
0.25 ± 0.02+
Significantly compared with original paw volume at .
+Significantly compared with nontreated control group at . cc: cubic centimeter.
