Research Article
Substrate Directed Regioselective Monobromination of Aralkyl Ketones Using N-Bromosuccinimide Catalysed by Active Aluminium Oxide: α-Bromination versus Ring Bromination
Table 2
Effect of solvent on α-bromination of acetophenonea.
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Reaction conditions: acetophenone 1a (10 mmol), N-bromosuccinimide (12 mmol), 10% (w/w) acidic Al2O3, and solvent (20 vol) at reflux temperature. bIsolated yield. cReaction was conducted at 32°C. dFreshly distilled ether and THF were used (peroxide free). |