Ixora coccinea Enhances Cutaneous Wound Healing by Upregulating the Expression of Collagen and Basic Fibroblast Growth Factor

Table 3

Histopathological evaluation of wound healing process in different treatment groups.

Groups	Wound healing process
	S	U	Ed	PMC	MNC	FP	RE	CD
Day 7
Nontreated	++	++	++	+++	+	+	−	−
Vehicle control	++	++	++	+++	+	+	+/−	−/+
IxME (2.5%)	+	−	−	++	++	+++	++	++
Gentamicin sulfate (0.01%)	+	−	−	++	++	++	+	+
Day 15
Nontreated	++	+	−/+	++	+++	++	+	++
Vehicle control	+	+	−	++	+++	++	++	++
IxME (2.5%)	−	−	−	−	+	+++	+++	+++
Gentamicin sulfate (0.01%)	−	−	−	−/+	+	++	++	++

HE and MT staining were scored as mild (+), moderate (++), and severe (+++) for epidermal and/or dermal re-modeling. S: scab; U: ulcer; Ed: edema; PMC: polymorphonuclear cells; MNC: mononuclear cells; FP: fibroblast proliferation; CD: collagen deposition; RE: reepithelialization; IxME: I. coccinea methanol extract.