Preventative Effects of Caffeic Acid Phenyl Ester on Cadmium Intoxication Induced Hematological and Blood Coagulation Disturbances and Hepatorenal Damage in Rats

Table 1

Hematological and blood coagulation findings.

Parameter	Units	Control group; (𝑛=10)	Cd group; (𝑛=15)	Cd + CAPE group; (𝑛=15)
WBC	10^3/𝜇L	11.92±0.79	13.53±2.72	12.27±1.46
RBC	10^6/𝜇L	8.67±0.48	5.93 ± 0.83*	8.10 ± 0.16^#
HGB	g/L	157.67±7.23	115.46 ± 6.03*	151.67 ± 3.51^#
HCT	%	48.33±0.71	41.83 ± 1.00*	46.13 ± 1.01^#
MCV	fL	64.27±0.84	52.87 ± 4.48*	60.20 ± 1.54^#
MCH	pg	22.13±1.65	16.70 ± 1.11*	20.40 ± 1.20^#
MCHC	g/L	344.42±39.50	300.26 ± 27.77*	337.67 ± 38.50^#
PLT	10^3/𝜇L	1000.27±91.83	775.32 ± 59.61*	933.36 ± 70.76^#
PT	Second	12.82±1.37	43.14 ± 4.33*	17.76 ± 2.33^#
APTT	Second	21.73±3.46	77.52 ± 13.43*	29.36 ± 5.21^#
FIB	mg/dL	263.90±33.77	93.37 ± 9.37*	226.68 ± 42.23^#

The values are presented as means ± SD. (Cd) cadmium, (CAPE) caffeic acid phenyl ester, (WBC) white blood cell, (RBC) red blood cell, (HGB) hemoglobin, (HCT) hematocrit, (MCV) mean corpuscular volume, (MCH) mean corpuscular hemoglobin, (MCHC) mean corpuscular hemoglobin concentration, (PLT) platelet, (PT) prothrombin time, (APTT) activated partial thromboplastin time, and (FIB) fibrinogen. *𝑃<0.05 versus control group; ^#𝑃<0.05 versus Cd group.