The Human Epidermal Growth Factor Receptor 2 Screening Tests for Breast Cancer Suggested by the New Updated Recommendation of the American Society of Clinical Oncology/College of American Pathologists Will Involve a Rise of the In-Situ Hybridization Tests for the European Laboratories of Pathology

Table 2

Comparison and correspondence between 2007 and 2013 recommendations systems for immunohistochemistry.

		2013 guidelines
		0+	1+	2+	3+	Total
2007 guidelines	0+	17	2	0	0	19
	1+	0	52	65	1	118
	2+	0	0	24	16	40
	3+	0	0	0	9	9
	Total	17	54	89	26	186

The data shows the changes of 1+ IHC to 2+ IHC (𝑛=65) and the 2+ IHC to 3+ IHC (𝑛=16), respectively, between the 2007 and the 2013 recommendations.