The Human Epidermal Growth Factor Receptor 2 Screening Tests for Breast Cancer Suggested by the New Updated Recommendation of the American Society of Clinical Oncology/College of American Pathologists Will Involve a Rise of the In-Situ Hybridization Tests for the European Laboratories of Pathology

Table 3

Comparison and correspondence between 2007 and 2013 recommendations systems for fluorescence in situ hybridization.

		2013 guidelines
		E	N	P	Total
2007 guidelines	E	1	3	4	8
	N	1	145	2	148
	P	0	0	33	33
	Total	2	148	39	186

Kappa test between the 2 ASCO/CAP versions is excellent: 0.96 (95% CI: 0.91–1.0). There are less equivocal results with the 2013 recommendations.
E: equivocal, N: negative, and P: positive.
Note: the decrease of equivocal FISH of the 2013. Two negative cases became positive because the means of HER2 gene were more than 4 copies.