Table of Contents
International Scholarly Research Notices
Volume 2014, Article ID 820387, 5 pages
Research Article

Effect of Aerobic Exercise Training on MDA and TNF-α Levels in Patients with Type 2 Diabetes Mellitus

1Department of Internal Medicine, Develi State Hospital, 38400 Kayseri, Turkey
2Division of Endocrinology and Metabolism, Faculty of Medicine, Selcuk University, 42250 Konya, Turkey
3Department of Internal Medicine, Faculty of Medicine, Baskent University, 42080 Konya, Turkey
4Department of Biochemistry, Meram School of Medicine, Necmettin Erbakan University, 42090 Konya, Turkey
5Division of Endocrinology and Metabolism, Faculty of Medicine, Istanbul Bilim University, 34394 Istanbul, Turkey

Received 11 April 2014; Accepted 28 July 2014; Published 21 October 2014

Academic Editor: Marco Guazzi

Copyright © 2014 Mihriban Arslan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Diabetes mellitus (DM) is associated with low-grade inflammation. The benefits of regular exercise for the DM are well established, whereas less is known about the impact of aerobic exercise on malondialdehyde (MDA) and tumor necrosis factor-alpha (TNF-α) in the DM. Methods. We randomised 64 participants, who do not exercise regularly, without any diabetic chronic complications in parallel to 12 weeks of aerobic exercise (three times per week, ) and no exercise (control; ). Plasma levels of soluble TNF-α and MDA levels were measured before-after physical training programme and control group. Results. Sixty-four patients with type 2 diabetes mellitus were analysed. When comparing the two groups of patients with age, gender, hemoglobin A1c (HbA1c) levels, lipid profile, waist circumference, body mass index (BMI) and class of treatment for diabetes were not different between groups. While soluble TNF-α remained essentially unaffected by physical training, plasma concentrations of MDA markedly decreased ; physical training also decreased body weight, waist circumference, and blood pressure . Conclusion. Exercise training favorably affected body weight, waist circumference, and blood pressure. A three-weekly, 12-week, aerobic-training programme, without a concomitant weight loss diet, was associated with significant decrease in MDA levels in type 2 diabetic individuals.