|
| | APA | Canadian | NICE | Maudsley | Unified |
|
| Bipolar, manic episode-acute treatment | Li/Valp/CBZ ER ± AP (OLZ/Risp/Quet/Arip/Zipr) | OLZ/Risp/Quet | OLZ/Risp/Quet/Li/Valp | Valp/Li/Li or Valp + AP/OLZ/Risp/Quet | Li/Valp/OLZ/Risp/Quet |
|
| Bipolar, mixed episode-acute treatment | Valp/Li/CBZ ER ± antipsychotic | Divalproex/OLZ | Valp/OLZ | Valp/OLZ | Valp/OLZ |
|
| Bipolar, depressive episode-acute treatment | Li/LMTG/OLZ + FXT/Quet | Li/LMTG/Li + SSRI/Bupropion/OLZ + SSRI/Quet | Li + SSRI/Valp + SSRI/Quet | Li/Li + antidepressant/LMTG/OLZ + FXT/Quet | Li/Li + SSRI/LMTG/OLZ + FXT/Quet |
|
| Rapid cycling | Li/Valp/LMTG | No recommendations | Li + Valp | No recommendations | Li/Valp |
|
| Maintenance of bipolar, manic episodes | Lithium/OLZ | Li/Divalproex + antipsychotic (Risp/OLZ/Quet) | Lithium/Valp/OLZ | Lithium/Valp/OLZ | Li/Valp/OLZ |
|
| Maintenance of bipolar, depressive episodes | LMTG | LMTG/Li/Divalproex + SSRI | Li/Valp + LMTG/Quet | Li/Valp/LMTG/Quet | LMTG/Li/Valp/Quet |
|
| Duration | Acute phase: 6 to 12 weeks
Continuation phase: 6–9 months
Maintenance phase: 1 to 2 years to lifetime | Acute phase: 8 to 12 weeks; continuation phase: 4–6 months
Maintenance phase: 1 to 2 years to lifetime | No mention of duration of treatment of acute episode. Long term treatment for at least 2 years after an episode and up to 5 years in case of other risk factors | Same as NICE | Acute phase: up to 12 weeks
Continuation phase: up to 9 months.
Maintenance phase: 2 years for 1st and 5 years to lifetime for subsequent episodes |
|
| Psychosocial management | Family focused therapy | Psychoeducation + CBT/IPT/FFT | FFT/CBT (16–20 sessions) | No recommendations | FFT/CBT |
|
