Factor VIII-Related Antigen Detects Phenotypic Change of Sinusoidal to Vascular Endothelium in Hepatic Fibrosis of Elderly Cadavers
Figure 6
(a) Periportal parenchyma. FVIIIRAg immunoreactive sinusoidal endothelial cells are seen in loose aggregate close by the portal tract, PT. The immune deposits of FVIIIRAg (brown color) are patchy and discontinuous along the sinusoidal lining. Note FVIIIRAg immunostained blood vessels (arrows) in the portal tract. (b) Developing septum and periseptal parenchyma. FVIIIRAg immunoreactive sinusoids (brown color) can be seen nearby the septum, ST, particularly in the parenchyma around the growing front of the septum. The immunostaining reaction appears patchy and discontinuous along the sinusoidal lining. Note immunoreactive blood vessels (arrows) in the septum. (c) Bridging septum and periseptal parenchyma. This shows FVIIIRAg-positive endothelial cells (brown color) in the sinusoids in the vicinity of the septum, ST.
