Can HLA-DRB4 Help to Identify Asthmatic Patients at Risk of Churg-Strauss Syndrome?
Table 3
Main clinical and laboratory characteristics of the 60 HLA-DRB4 positive and 99 HLA-DRB4 negative asthmatic patients. Categorical variables are reported as percentage.
DRB4 positive
DRB4 negative
OR
95% CI
Severe persistent asthma before treatment
26.7
12.1
<0.02
2.64
1.48–6.06
Emergency admission for near fatal or severe hypoxaemic asthma
20.0
5.0
<0.01
4.7
1.57–14.12
Chronic rhinosinusitis
35.0
16.2
<0.01
2.79
1.31–5.93
History of nasal polypectomy
31.7
14.1
<0.01
2.81
1.28–6.17
Patients with eosinophils > 1000/L
23.3
11.1
<0.05
2.43
1.02–5.79
Beclomethasone > 1000 g daily°
41.7
15.2
<0.001
4
1.89–8.48
LABA
86.7
76.7
0.12
1.97
0.82–4.74
Third controller
21.7
10.1
<0.05
2.46
1.00–6.04
Continuous or near continuous (>50% of year) prednisone
