Stability-Indicating HPLC Method for the Simultaneous Determination of HIV Tablet Containing Emtricitabine, Tenofovir Disoproxil Fumarate, and Rilpivirine Hydrochloride in Pharmaceutical Dosage Forms

<table class="figure-group"><tr class="fig-image" id="a"><td><object data="https://static.hindawi.com/articles/isrn/volume-2014/849149/figures/849149.fig.002a.svgz" name="849149.fig.002a" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td>(a) Acid hydrolytic degradation</td></tr><tr class="fig-image" id="b"><td><object data="https://static.hindawi.com/articles/isrn/volume-2014/849149/figures/849149.fig.002b.svgz" name="849149.fig.002b" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td>(b) Base hydrolytic degradation</td></tr><tr class="fig-image" id="c"><td><object data="https://static.hindawi.com/articles/isrn/volume-2014/849149/figures/849149.fig.002c.svgz" name="849149.fig.002c" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td>(c) Neutral hydrolytic degradation</td></tr><tr class="fig-image" id="d"><td><object data="https://static.hindawi.com/articles/isrn/volume-2014/849149/figures/849149.fig.002d.svgz" name="849149.fig.002d" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td>(d) Oxidation degradation</td></tr><tr class="fig-image" id="e"><td><object data="https://static.hindawi.com/articles/isrn/volume-2014/849149/figures/849149.fig.002e.svgz" name="849149.fig.002e" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td>(e) Thermal degradation</td></tr><tr class="fig-image" id="f"><td><object data="https://static.hindawi.com/articles/isrn/volume-2014/849149/figures/849149.fig.002f.svgz" name="849149.fig.002f" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td>(f) Photolytic degradation</td></tr></table>

<div>HPLC chromatographic separation of TDF, EMT, and RPV and its degradation product in different stress conditions.[The labeling of degradation products from its original source. For instance, emtricitabine (E1 E2 &amp; E3), tenofovir (T1 T2 &amp; T3) and rilpivirine (R1 R2 &amp; R3)].</div>

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Figure 2

Figure 2: Stability-Indicating HPLC Method for the Simultaneous Determination of HIV Tablet Containing Emtricitabine, Tenofovir Disoproxil Fumarate, and Rilpivirine Hydrochloride in Pharmaceutical Dosage Forms 

Figure 2 | Stability-Indicating HPLC Method for the Simultaneous Determination of HIV Tablet Containing Emtricitabine, Tenofovir Disoproxil Fumarate, and Rilpivirine Hydrochloride in Pharmaceutical Dosage Forms 