Table of Contents
International Scholarly Research Notices
Volume 2014, Article ID 875670, 4 pages
Clinical Study

Single Dose of Levofloxacin versus Three Dosages for Prophylaxis in Prostate Biopsy

Urology Department, Centro Medico Nacional “20 de Noviembre” México, Félix Cuevas 540, Del Valle, Benito Juárez, 03100 Ciudad de México, DF, Mexico

Received 23 April 2014; Accepted 23 June 2014; Published 3 September 2014

Academic Editor: Gabriel Sandblom

Copyright © 2014 Edgar Linden-Castro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Transrectal ultrasound-guided core prostate biopsy is a key event in the diagnosis of prostate cancer, transient side events such as local pain, haematuria, haematospermia, dysuria, and rectal bleeding are reported in a large number of patients. Antimicrobial agents lower the incidence of postbiopsy infectious complications. The timing and duration of the regimen and the route of administration remain controversial. We developed a standard prophylactic regimen, in which safety and efficiency were maximized, while costs and variability were minimized. Accordingly we prospectively evaluated 425 consecutive patients, who underwent outpatient transrectal ultrasound-guided prostate biopsy after a single dose versus three doses of levofloxacin.