Clinical Study
Parameters Associated with Significant Liver Histological Changes in Patients with Chronic Hepatitis B
Table 1
Characteristics of 157 patients included in the study.
| | Variables | Total | A0-A1 | A2-A3 | F0-F1 | F2–F4 |
| | Number of patients | 157 | 48 | 109 | 81 | 76 | | Age (years) | 38 (14–68) | 36 (14–58) | 39 (18–68) | 36 (14–64) | 41 (25–68) | | Gender (male) | 136 (87%) | 40 (83%) | 96 (91%) | 68 (84%) | 68 (89%) | | HBeAg+ | 68 (43%) | 21 (44%) | 47 (43%) | 41 (51%) | 27 (36%) | | HBeAg− | 89 (57%) | 27 (56%) | 62 (57%) | 40 (49%) | 49 (64%) | | HBV DNA (log copies/mL) | 6 (2–9) | 5.5 (3–9) | 6 (2–9) | 6 (2–9) | 5.5 (2–8) | | PT (sec) | 13 (8.2–17.8) | 13 (8.2–16) | 13.1 (9.2–17.8) | 12.8 (8.2–16.7) | 13.7 (9.5–17.8) | | ALB (g/L) | 42.5 (30.1–53.9) | 43.3 (33.5–53.7) | 42 (30.1–53.9) | 43.3 (33.3–53.9) | 41.15 (30.1–48.9) | | GLOB (g/L) | 31.2 (21.9–48.2) | 30.5 (23.3–48.1) | 31.9 (21.9–48.2) | 30.2 (21.9–45.9) | 33.1 (23.9–48.2) | | TB (umol/L) | 16.2 (5.9–218) | 14.5 (6.1–84.7) | 16.3 (5.9–218) | 14.3 (5.9–218) | 18.1 (6.1–170.5) | | TP (g/L) | 74.1 (59.5–92.5) | 75.3 (64.4–92.5) | 74 (59.5–87.1) | 74 (60.6–92.5) | 74.6 (59.5–89.3) | | ALT (IU/L) | 69 (13–1387) | 64 (18–1387) | 72 (13–1215) | 62 (13–1387) | 71 (17–999) | | AST (IU/L) | 46 (14–723) | 44.5 (16–658) | 47 (14–723) | 40 (14–571) | 58 (17–723) | | ALP (IU/L) | 79 (35–323) | 73 (35–323) | 80 (41–258) | 74 (35–323) | 88 (42–258) | | GGT (IU/L) | 43 (7–476) | 38 (7–467) | 46 (11–402) | 30 (7–476) | 62 (15–402) | | PLT /L) | 115 (19–314) | 122.5 (43–257) | 114 (19–314) | 132 (28–257) | 97 (19–314) | | WBC (/L) | 4.69 (1.96–7.77) | 4.68 (2.73–7.64) | 4.7 (1.96–7.77) | 5.11 (2.4–7.77) | 4.32 (1.96–7.64) |
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Continuous variables are expressed as the median (range).
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