Research Article

Antinociceptive Effects of the Serotonin and Noradrenaline Reuptake Inhibitors Milnacipran and Duloxetine on Vincristine-Induced Neuropathic Pain Model in Mice

Figure 3

(Top) Schedule of drug administration. (Bottom) Vincristine (VCR; 0.1 mg/kg, i.p.) and milnacipran (Mil; 10, 20, or 40 mg/kg, i.p.) were coadministered once per day for 7 days (days 0–6) to mice (a). Milnacipran (Mil; 10, 20, or 40 mg/kg, i.p.) was administered to mice once per day for 7 days (days 7–13) after cessation of VCR (0.1 mg/kg, i.p.) administered once per day for 7 days (days 0–6) to mice (b). On day 7 (a) and day 14 (b), withdrawal responses to mechanical stimulation using a von Frey filament (0.4 g) were measured. Data are presented as mean ± S.E.M. for 10 mice in each group. Significant differences between the groups were assessed with one-way ANOVA followed by Dunnett’s test. compared with the saline control group; and compared with the VCR group.
915464.fig.003a
(a)
915464.fig.003b
(b)