Table of Contents
ISRN Cardiology
Volume 2014, Article ID 919150, 4 pages
http://dx.doi.org/10.1155/2014/919150
Clinical Study

Myocardial Injury in Critically Ill Children: A Case Control Study

1Pediatrics Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt
2Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt

Received 9 December 2013; Accepted 30 December 2013; Published 11 February 2014

Academic Editors: J. A. F. Ramires and M.-S. Suleiman

Copyright © 2014 Basheir Hassan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. The aim of this study was to investigate the occurrence of myocardial injury in critically ill children through assessment of cardiac troponin T levels and whether levels are associated with disease severity and myocardial dysfunction measured by echocardiography. Methods. Over a 6-month period, this case control study included 50 patients admitted to Pediatric Intensive Care Unit of Zagazig University Children’s Hospital. Twenty-five healthy children were included as a control group. Demographic and clinical data including the pediatric index of mortality II score were recorded. Echocardiographic examination was done and level of cardiac troponin T was measured using Elecsys Troponin T STAT Immunoassay. Results. Cardiac troponin T levels were significantly higher in critically ill in comparison to healthy children (median 22 (18–28) pg/mL versus 10 (10-10) pg/mL, ). Cardiac troponin T levels correlated positively with duration of ventilation as well as with disease severity and correlated negatively with left ventricular fractional shortening. Moreover, cardiac troponin T levels were significantly higher in nonsurvivors when compared to survivors (median 34.5 (27.5–41.5) pg/mL versus 20 (18–24) pg/mL, ). Conclusion. In critically ill children, cardiac troponin T levels were elevated and were associated with duration of ventilation and disease severity.