Table of Contents
ISRN Surgery
Volume 2014 (2014), Article ID 930803, 7 pages
http://dx.doi.org/10.1155/2014/930803
Research Article

Randomized, Controlled Comparison of Advanced Hemostatic Pads in Hepatic Surgical Models

1Baxter Healthcare Corporation, One Baxter Parkway, Deerfield, IL 60015, USA
2Baxter Innovations GmbH, Industriestraße 67, 1221 Vienna, Austria

Received 3 January 2014; Accepted 23 January 2014; Published 4 March 2014

Academic Editors: J. E. Losanoff and J. A. Tovar

Copyright © 2014 Kevin M. Lewis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Blood loss during hepatic surgery leads to poor patient outcomes. This study investigates the hemostatic efficacy of a novel sealing hemostatic pad (polyethylene glycol-coated collagen, PCC) and a fibrin sealant pad (fibrin-thrombin coated collagen, FTC) in a leporine hepatic segmentectomy and a porcine hepatic abrasion model. A segmentectomy was used to compare hemostatic success and hematoma incidence in 20 rabbits (10/group). Hepatic abrasions were used to compare hemostatic success up to 10 min after application in six pigs (42 lesions/group). In the segmentectomy model, PCC achieved 100% hemostatic success within 2 min (95% CI: 72.3% to 100%) and FTC achieved 80% hemostatic success within 3 min (49.0% to 94.3%). PCC had lower hematoma incidence at 15 min (0.0 versus 11.1%) and 24 h (20.0 versus 66.7%). In the abrasion model, PCC provided superior hemostatic success at 3 (odds ratio: 24.8, 95% CI: 8.86 to 69.2, ), 5 (66.3, 28.5 to 153.9, ), 7 (177.5, 64.4 to 489.1, ), and 10 min (777.6, 148.2 to 4078, ) leading to statistically significant less blood loss. The novel sealing hemostat provides faster and more sustained hemostasis than a fibrin sealant pad in a leporine hepatic segmentectomy and a porcine hepatic abrasion model of hepatic surgery.