Randomized, Controlled Comparison of Advanced Hemostatic Pads in Hepatic Surgical Models

Table 1

Differences between Hemopatch and TachoSil at 3, 5, 7, and 10 minutes after application in hemostatic success and bleeding rates after controlling for pretreatment bleeding rate. Hemopatch had superior hemostatic success relative to TachoSil at all-time points based on the odds ratio of success, where a lower 95% confidence interval greater than one indicates superiority of Hemopatch. Hemopatch had significantly less blood loss than TachoSil at all-time points based on the difference of blood loss, where an upper 95% confidence interval less than zero indicates statistical significance.

Time after application	Hemostatic success (odds ratio: Hemopatch/TachoSil)			Difference of bleeding rate (difference: Hemopatch-TachoSil)
	Odds ratio	Two-sided 95% confidence interval for odds ratio	Two-sided; 𝑃 value	Difference (mL/min)	Two-sided 95% confidence interval for difference (mL/min)	Two-sided; 𝑃 value
3	24.8	8.86 to 69.2	<0.001	−0.32	−0.47 to −0.17	<0.001
5	66.3	28.5 to 153.9	<0.001	−0.56	−0.74 to −0.37	<0.001
7	177.5	64.4 to 489.1	<0.001	−0.79	−1.03 to −0.55	<0.001
10	777.6	148.2 to 4078	<0.001	−1.14	−1.49 to −0.79	<0.001