Factorial Design Studies and Biopharmaceutical Evaluation of Simvastatin Loaded Solid Lipid Nanoparticles for Improving the Oral Bioavailability

Table 2

Characterization of solid lipid nanoparticles.

Batch code	Poloxamer (mg)	Soya lecithin (mg)	Drug content %	Size distribution (nm)	Zeta potential (mV)	Polydispersibility
F1	100	200	99.12±0.12	125.6±1.25	−45±4.14	0.227±0.60
F2	100	150	96.02±0.11	110.8±1.83	−22±0.65	0.175±0.22
F3	100	100	101.7±0.2	157.8±0.07	−25.1±1.2	0.254±0.13
F4	150	200	99.2±0.13	102.7±1.75	−35.3±0.6	0.287±0.24
F5	150	150	100±0.22	101.7±1.30	−31.3±0.8	0.201±0.14
F6	150	100	98.22±0.05	358.2±2.05	−38±1.0	0.445±0.52
F7	200	200	100.2±0.11	99.7±0.9	−31.6±1.2	0.242±0.02
F8	200	150	99.13±0.02	108.8±0.20	−36.7±0.8	0.21±0.22
F9	200	100	101.02±0.08	104±0.08	−37.7±1.8	0.212±0.16

Note. *Results are expressed as mean ± standard deviation (𝑛=3).