Table of Contents
ISRN Pharmacology
Volume 2014, Article ID 952943, 9 pages
Review Article

A Review on Protocatechuic Acid and Its Pharmacological Potential

Department of Pharmacology , Rayat Institute of Pharmacy, Railmajra, District S.B.S. Nagar, Punjab 144533, India

Received 12 January 2014; Accepted 5 March 2014; Published 26 March 2014

Academic Editors: D. K. Miller and T. W. Stone

Copyright © 2014 Sahil Kakkar and Souravh Bais. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Flavonoids and polyphenols are heterocyclic molecules that have been associated with beneficial effects on human health, such as reducing the risk of various diseases like cancer, diabetes, and cardiovascular and brain diseases. Protocatechuic acid (PCA) is a type of widely distributed naturally occurring phenolic acid. PCA has structural similarity with gallic acid, caffeic acid, vanillic acid, and syringic acid which are well-known antioxidant compounds. More than 500 plants contain PCA as active constituents imparting various pharmacological activity and these effects are due to their antioxidant activities, along with other possible mechanisms, such as anti-inflammatory properties and interaction with several enzymes. Over the past two decades, there have been an increasing number of publications on polyphenols and flavonoids, which demonstrate the importance of understanding the chemistry behind the antioxidant activities of both natural and synthesized compounds, considering the benefits from their dietary ingestion as well as pharmacological use. This work aims to review the pharmacological effects of PCA molecules in humans and the structural aspects that contribute to these effects.