Table of Contents
ISRN Oxidative Medicine
Volume 2014 (2014), Article ID 961013, 9 pages
http://dx.doi.org/10.1155/2014/961013
Research Article

Plasma Aminothiol Profile and Some of Its Determinants in Apparently Healthy Azorean Subjects

Center of Research in Natural Resources (CIRN) and Department of Technological Sciences and Development, University of the Azores, Ponta Delgada, 9501-801 Azores, Portugal

Received 22 October 2013; Accepted 6 January 2014; Published 16 February 2014

Academic Editors: P. Leroy and N. Visavadiya

Copyright © 2014 Ana Lima et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Noël, E. Dewailly, M. L. Chateau-Degat, É. Counil, E. A. Laouan-Sidi, and E. Lonn, “Cardiovascular risk factors and subclinical atherosclerosis among Nunavik Inuit,” Atherosclerosis, vol. 221, no. 2, pp. 558–564, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. C. Ceconi, A. Boraso, A. Cargnoni, and R. Ferrari, “Oxidative stress in cardiovascular disease: myth or fact?” Archives of Biochemistry and Biophysics, vol. 420, no. 2, pp. 217–221, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. Özkan, E. Özkan, and B. Imşek, “Plasma total homocysteine and cysteine levels as cardiovascular risk factors in coronary heart disease,” International Journal of Cardiology, vol. 82, no. 3, pp. 269–277, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. M. E. McMenamin, J. Himmelfarb, and T. D. Nolin, “Simultaneous analysis of multiple aminothiols in human plasma by high performance liquid chromatography with fluorescence detection,” Journal of Chromatography B, vol. 877, no. 28, pp. 3274–3281, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. E. Bald, G. Chwatko, R. Głowacki, and K. Kuśmierek, “Analysis of plasma thiols by high-performance liquid chromatography with ultraviolet detection,” Journal of Chromatography A, vol. 1032, no. 1-2, pp. 109–115, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. E. Camera and M. Picardo, “Analytical methods to investigate glutathione and related compounds in biological and pathological processes,” Journal of Chromatography B, vol. 781, no. 1-2, pp. 181–206, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Atmaca, “Antioxidant effects of sulfur-containing amino acids,” Yonsei Medical Journal, vol. 45, no. 5, pp. 776–788, 2004. View at Google Scholar · View at Scopus
  8. J. Selhub, “Public health significance of elevated homocysteine,” Food and Nutrition Bulletin, vol. 29, no. 2, pp. S116–S125, 2008. View at Google Scholar · View at Scopus
  9. H. J. Forman, H. Zhang, and A. Rinna, “Glutathione: overview of its protective roles, measurement, and biosynthesis,” Molecular Aspects of Medicine, vol. 30, no. 1-2, pp. 1–12, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. D. Drogan, C. Weikert, J. Dierkes et al., “Plasma γ-glutamyltransferase, cysteinyl-glycine, and oxidized low-density lipoprotein: a pathway associated with myocardial infarction risk?” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 30, no. 10, pp. 2053–2058, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. O. Turgut, A. Yilmaz, K. Yalta, F. Karadas, and M. Birhan Yilmaz, “γ-Glutamyltransferase is a promising biomarker for cardiovascular risk,” Medical Hypotheses, vol. 67, no. 5, pp. 1060–1064, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. D. Drogan, C. Weikert, J. Dierkes et al., “Plasma γ-glutamyltransferase, cysteinyl-glycine, and oxidized low-density lipoprotein: a pathway associated with myocardial infarction risk?” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 30, no. 10, pp. 2053–2058, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Kaul, A. A. Zadeh, and P. K. Shah, “Homocysteine hypothesis for atherothrombotic cardiovascular disease. Not validated,” Journal of the American College of Cardiology, vol. 48, no. 5, pp. 914–923, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. P. M. Ueland, M. A. Mansoor, A. B. Guttormsen et al., “Reduced, oxidized and protein-bound forms of homocysteine and other aminothiols in plasma comprise the redox thiol status—a possible element of the extracellular antioxidant defense system,” Journal of Nutrition, vol. 126, no. 4, pp. 1281S–1284S, 1996. View at Google Scholar · View at Scopus
  15. L. Turell, S. Carballal, H. Botti, R. Radi, and B. Alvarez, “Oxidation of the albumin thiol to sulfenic acid and its implications in the intravascular compartment,” Brazilian Journal of Medical and Biological Research, vol. 42, no. 4, pp. 305–311, 2009. View at Google Scholar · View at Scopus
  16. M. S. Morris, M. F. Picciano, P. F. Jacques, and J. Selhub, “Plasma pyridoxal 5′-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004,” The American Journal of Clinical Nutrition, vol. 87, no. 5, pp. 1446–1454, 2008. View at Google Scholar · View at Scopus
  17. Institute of Medicine Food and Nutrition Board, Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline, National Academies Press, 1998.
  18. R. Ferin, M. L. Pavão, and J. Baptista, “Methodology for a rapid and simultaneous determination of total cysteine, homocysteine, cysteinylglycine and glutathione in plasma by isocratic RP-HPLC,” Journal of Chromatography B, vol. 911, pp. 15–20, 2012. View at Publisher · View at Google Scholar
  19. M. Kimura, K. Kanehira, and K. Yokoi, “Highly sensitive and simple liquid chromatographic determination in plasma of B6 vitamers, especially pyridoxal 5′-phosphate,” Journal of Chromatography A, vol. 722, no. 1-2, pp. 295–301, 1996. View at Google Scholar · View at Scopus
  20. W. T. Friedewald, R. I. Levy, and D. S. Fredrickson, “Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge,” Clinical Chemistry, vol. 18, no. 6, pp. 499–502, 1972. View at Google Scholar · View at Scopus
  21. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, “Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III),” Journal of the American Medical Association, vol. 285, no. 19, pp. 2486–2497, 2001. View at Google Scholar · View at Scopus
  22. S. E. Moriarty-Craige and D. P. Jones, “Extracellular thiols and thiol/disulfide redox in metabolism,” Annual Review of Nutrition, vol. 24, pp. 481–509, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. S. S. Dhawan, P. Eshtehardi, M. C. McDaniel et al., “The role of plasma aminothiols in the prediction of coronary microvascular dysfunction and plaque vulnerability,” Atherosclerosis, vol. 219, no. 1, pp. 266–272, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Shimizu, Y. Kiyohara, I. Kato et al., “Relationship between plasma glutathione levels and cardiovascular disease in a defined population: the Hisayama study,” Stroke, vol. 35, no. 9, pp. 2072–2077, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Pastore, G. Federici, E. Bertini, and F. Piemonte, “Analysis of glutathione: implication in redox and detoxification,” Clinica Chimica Acta, vol. 333, no. 1-2, pp. 19–39, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. D. W. Jacobsen, V. J. Gatautis, R. Green et al., “Rapid HPLC determination of total homocysteine and other thiols in serum and plasma: sex differences and correlation with cobalamin and folate concentrations in healthy subjects,” Clinical Chemistry, vol. 40, no. 6, pp. 873–881, 1994. View at Google Scholar · View at Scopus
  27. O. Stanger, W. Herrmann, K. Pietrzik et al., “Clinical use and rational management of homocysteine, folic acid, and B vitamins in cardiovascular and thrombotic diseases,” Zeitschrift fur Kardiologie, vol. 93, no. 6, pp. 439–453, 2004. View at Google Scholar · View at Scopus
  28. P. Giral, N. Jacob, C. Dourmap et al., “Elevated gamma-glutamyltransferase activity and perturbed thiol profile are associated with features of metabolic syndrome,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28, no. 3, pp. 587–593, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. E. Mosharov, M. R. Cranford, and R. Banerjee, “The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes,” Biochemistry, vol. 39, no. 42, pp. 13005–13011, 2000. View at Publisher · View at Google Scholar · View at Scopus
  30. D. H. Lee and D. R. Jacobs Jr., “Is serum gamma-glutamyltransferase a marker of exposure to various environmental pollutants?” Free Radical Research, vol. 43, no. 6, pp. 533–537, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. D. H. Lee, R. Blomhoff, and D. R. Jacobs Jr., “Is serum gamma glutamyltransferase a marker of oxidative stress?” Free Radical Research, vol. 38, no. 6, pp. 535–539, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. H. Sakuta, T. Suzuki, and T. Ito, “Serum γ-glutamyl transferase is associated with plasma total homocysteine in Japanese patients with type 2 diabetes,” Acta Diabetologica, vol. 44, no. 4, pp. 177–180, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. R. Castro, M. Barroso, M. Rocha et al., “The TCN2 776C>G polymorphism correlates with vitamin B12 cellular delivery in healthy adult populations,” Clinical Biochemistry, vol. 43, no. 7-8, pp. 645–649, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. R. Clarke, J. Grimley Evans, J. Schneede et al., “Vitamin B12 and folate deficiency in later life,” Age and Ageing, vol. 33, no. 1, pp. 34–41, 2004. View at Publisher · View at Google Scholar · View at Scopus
  35. R. Castro, I. Rivera, P. Ravasco et al., “5,10-methylenetetrahydrofolate reductase 677C → T and 1298A → C mutations are genetic determinants of elevated homocysteine,” Monthly Journal of the Association of Physicians, vol. 96, no. 4, pp. 297–303, 2003. View at Publisher · View at Google Scholar · View at Scopus
  36. J. F. Cascalheira, M. C. Parreira, A. N. Viegas, M. C. Faria, and F. C. Domingues, “Serum homocysteine: relationship with circulating levels of cortisol and ascorbate,” Annals of Nutrition and Metabolism, vol. 53, no. 1, pp. 67–74, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. H. S. Sang, S. K. Ihm, J. K. Yun et al., “Can γ-glutamyltransferase be an additional marker of arterial stiffness?” Circulation Journal, vol. 71, no. 11, pp. 1715–1720, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. S. Lussier-Cacan, M. Xhignesse, A. Piolot, J. Selhub, J. Davignon, and J. Genest Jr., “Plasma total homocysteine in healthy subjects: sex-specific relation with biological traits,” The American Journal of Clinical Nutrition, vol. 64, no. 4, pp. 587–593, 1996. View at Google Scholar · View at Scopus
  39. N. Jacob, E. Bruckert, P. Giral, M. J. Foglietti, and G. Turpin, “Cysteine is a cardiovascular risk factor in hyperlipidemic patients,” Atherosclerosis, vol. 146, no. 1, pp. 53–59, 1999. View at Publisher · View at Google Scholar · View at Scopus
  40. W. E. Van den Brandhof, K. Haks, E. G. Schouten, and P. Verhoef, “The relation between plasma cysteine, plasma homocysteine and coronary atherosclerosis,” Atherosclerosis, vol. 157, no. 2, pp. 403–409, 2001. View at Publisher · View at Google Scholar · View at Scopus
  41. A. Zeljkovic, J. Vekic, V. Spasojevic-Kalimanovska et al., “LDL and HDL subclasses in acute ischemic stroke: prediction of risk and short-term mortality,” Atherosclerosis, vol. 210, no. 2, pp. 548–554, 2010. View at Publisher · View at Google Scholar · View at Scopus