Phenolic Acids (Gallic and Tannic Acids) Modulate Antioxidant Status and Cisplatin Induced Nephrotoxicity in Rats

Table 1

Effect of tannic and gallic acids on renal function test in normal and cisplatin induced nephrotoxic rats.

Groups	Treatments	Creatinine (mg/dl)	Urea (mg/dl)	U/A (mg/dl)
1	Normal control	44.04  ±  1.2	6.82  ±  0.8	7.12  ±  1.9
2	Induced control	131.49^b±  2.3	8.51^b±  0.7	11.09^b±  2.2
3	20 mg gallic acid + cisplatin	47.23^c±  1.8	7.05^c±  1.0	5.81^c±  0.8
4	40 mg gallic acid + cisplatin	20.43^c±  2.7	6.29^c±  1.5	4.96^c±  0.9
5	40 mg gallic acid only	16.59  ±  3.1	6.04  ±  1.6	4.80  ±  1.4
6	20 mg tannic acid + cisplatin	67.66^c±  2.3	7.31^c±  0.5	8.24^c±  3.5
7	40 mg tannic acid + cisplatin	11.49^c±  1.7	7.04^c±  0.5	4.33^c±  0.7
8	40 mg tannic acid only	7.66 ±  0.4	6.53  ±  0.4	5.37  ±  1.3

Values represent mean ± standard deviation (). ^bSignificantly () different from the normal control. ^cSignificantly () different from the induced control.