Perinatal Outcome in Women with Hypertensive Disorders of Pregnancy: A Retrospective Cohort Study
Table 2
Association of perinatal mortality with selected laboratory findings, treatment modalities, and outcome among women with hypertensive disorders of pregnancy, Ethiopia, 2008–2013.
Variables*
Total
Perinatal deaths (%)
Crude HR (95% CI)
Adjusted** HR (95% CI)
Hemoglobin level (gm/dL)
<10.0
158
36.1
1.0 (0.71–1.51)
10–11.9
255
26.7
0.7 (0.51–1.00)
≥12
602
32.7
1
Platelet count in mm3
<100
223
47.5
2.3 (1.66–3.31)†
1.5 (0.83–2.85)
≥100
792
27.3
1
1
Proteinuria (qualitative)
Insignificant
266
27.1
1
Significant
749
30.4
1.2 (0.89–1.68)
Highest creatinine (gm/dL)
<1.0
494
26.3
1
1
1.0+
521
36.8
1.5 (1.05–2.03)¥
0.8 (0.51–1.39)
Highest SGOT (IU/microl)
<2-fold raise
689
24.5
1
1
≥2-fold raise
326
46.9
2.9 (1.96–4.22)†
2.3 (1.30–3.91)‡
Antihypertensive drug given
Yes
811
32.8
1
No
204
27.5
0.8 (0.55–1.11)
Anticonvulsant drug given
MgSO4
641
30.6
1
Diazepam
374
33.7
1.1 (0.81–1.41)
Labor onset
Spontaneous
331
26.3
2.3 (1.49–3.78)†
0.7 (0.25–2.07)
Induced
504
41.1
4.9 (3.16–7.49)†
1.6 (0.69–3.81)
Direct C/S
180
15.6
1
1
Mode of delivery
Vaginal
625
41.1
4.5 (3.32–6.13)†
5.3 (2.93–9.54)†
Caesarean section
485
13.4
1
1
Birth weight (kg)
<2.5
545
42.7
4.1 (3.02–5.45)†
4.3 (2.56–7.23)†
2.5+
565
15.7
1
1
Maternal outcome
Alive on discharge
964
29.0
1
1
Dead
51
82.3
7.1 (3.79–13.38)†
12.8 (2.99–54.49)‡
< 0.05; ‡ = 0.001; † < 0.0001. *All variables describe the mother’s condition except mode of delivery and birth weight. **Adjusted for platelet count, creatinine level, SGOT level, labor onset, mode of delivery, birth weight, and maternal outcome. C/S: Caesarean section. SGOT: serum glutamic oxaloacetic transaminase.
