Table of Contents
International Scholarly Research Notices
Volume 2015 (2015), Article ID 261476, 8 pages
http://dx.doi.org/10.1155/2015/261476
Research Article

Novel Starch-PVA Polymer for Microparticle Preparation and Optimization Using Factorial Design Study

Department of Chemical Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India

Received 13 August 2014; Revised 21 October 2014; Accepted 27 October 2014

Academic Editor: Srinivas Mutalik

Copyright © 2015 Helen Chattopadhyay et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of our present work was to optimize the ratio of a very novel polymer, starch-polyvinyl alcohol (PVA), for controlled delivery of Ornidazole. Polymer-coated drug microparticles were prepared by emulsion method. Microscopic study, scanning electron microscopic study, and atomic force microscopic study revealed that the microparticles were within 10 micrometers of size with smooth spherical shape. The Fourier transform infrared spectroscopy showed absence of drug polymer interaction. A statistical 32 full factorial design was used to study the effect of different concentration of starch and PVA on the drug release profile. The three-dimensional plots gave us an idea about the contribution of each factor on the release kinetics. Hence this novel polymer of starch and polyvinyl alcohol can be utilized for control release of the drug from a targeted delivery device.