Table of Contents
International Scholarly Research Notices
Volume 2015, Article ID 286076, 7 pages
http://dx.doi.org/10.1155/2015/286076
Research Article

A Kinetic Model of Whole-Body Glucose Metabolism with Reference to the Domestic Dog (Canis lupus familiaris)

1Centre for Nutrition Modelling, Department of Animal & Poultry Science, University of Guelph, 50 Stone Road East, Guelph, ON, Canada N1G 2W1
2The Iams Company, Mason, OH 45040, USA
3Instituto de Ganadería de Montaña (CSIC-ULE), Departamento de Producción Animal, Universidad de León, 24071 León, Spain

Received 17 April 2015; Accepted 18 May 2015

Academic Editor: Rui Curi

Copyright © 2015 Leslie L. McKnight et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A new two-pool model to describe glucose kinetics in the steady state is presented. The pools are plasma glucose, Q1, and tissue glucose, Q2 (both µmol). The flows (all µmol/min) into the plasma pool (Pool 1) are absorbed glucose entry from dietary sources, labelled glucose infusion, and hepatic glucose production. There is one flow out of Pool 1, glucose uptake by the tissues. Inflows to the tissues pool (Pool 2) are from plasma and glycogenolysis. Outflows from Pool 2 are to plasma, glucose oxidation, and glycogenesis and other metabolism. Application of the model was illustrated using experimental data derived from healthy adult Labrador Retrievers in the fasted and fed (repeated meal feeding) states. In general, model derived estimates of glucose kinetics were representative of normal glucose metabolism, where rates of glucose production and uptake are similar and act to maintain blood glucose concentrations. Furthermore, estimates of within tissue glucose cycling indicated glycogenolysis in fasting and glycogenesis when fed. In the fasted state, model outputs were consistent with those reported in the canine literature derived using a single pool model.