A Kinetic Model of Whole-Body Glucose Metabolism with Reference to the Domestic Dog (Canis lupus familiaris)

Table 5

Plasma glucose rate of appearance (, μmol/(min·kg)) and glucose oxidation (Ox, μmol/(min·kg)) reported in the canine literature (data means are presented).

Reference	Experimental groups (conditions)	BW, kg		Ox
[14]	2-^3H [basal; methylprednisolone]	21.1	22; 40.1	—
	3-^3H [basal; methylprednisolone]	21.1	14.4; 18.4	—
	U-^14C [basal; methylprednisolone]	21.1	14.4; 19.3	—
[15]	Healthy; obese	12.2; 17.5	15.6; 13.9	—
[13]	Clamped euglycemia [0; 7; 40; 120 mU/kg/h constant insulin infusion]	22	19.1; 17.9; 54.7; 101.7	—
	Clamped hyperglycemia [0; 7; 40; 120 mU/kg/h constant insulin infusion]	22	36; 46.1; 96.1; 167.8	—
[16]	Healthy [saline; AICAR^†; methypalmoxirate; AICAR and methypalmoxirate]	20.1	13; 17.5; 14.5; 16	—
	Diabetic [saline; AICAR; methypalmoxirate; AICAR and methypalmoxirate]	20.1	32.4; 31.6; 23.6; 21.9	—
[17]	Saline infusion; pulsatile; constant octanoate infusion	—	16.7; 18.3; 14.4	—
[18]	Baseline; 6 wk; 12 wk moderate-fat feeding	27.5; —; 29	14.4; 18.3; 18.3	—
[19]	Saline; nicotinic acid	—	15; 24	6; 14
[20]	Basal	20.4	12.7	—
[21]	Basal [U-^14C; 3-^3H]	15.2	8.7; 13.9	—
[22]	Basal	—	24.3	—
[23]	Basal [saline; high FFA^‡; low FFA infusion]	—	15.3; 15.3; 15.3	5; 4.8; 8.9
	Epinephrine infusion [saline; high FFA; low FFA infusion]	—	15; 15.8; 15.3	4.9; 5.2; 9.7
	Propranolol and phentolamine infusion [saline; high FFA; low FFA infusion]	—	15.2; 15.0; 15.2	5.1; 5.1; 9.8
	Overall mean and SE	20.9 ± 0.6	26.8 ± 4.3	7.1 ± 0.9

Basal refers to fasted rest.
^†AICAR: 5-aminoimidazole-4-carboxamide ribonucleotide.
^‡FFA: free fatty acids.