Table of Contents
International Scholarly Research Notices
Volume 2015, Article ID 469402, 6 pages
http://dx.doi.org/10.1155/2015/469402
Research Article

Assessment of Tachykinin Receptor 3′ Gene Polymorphism rs3733631 in Rosacea

1Department of Dermatology, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece
2Department of Medical Biology, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece
3Department of Medical Statistics, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece

Received 28 May 2015; Revised 31 August 2015; Accepted 3 September 2015

Academic Editor: Monika Dmitrzak-Weglarz

Copyright © 2015 Anthony Karpouzis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Rosacea is a chronic skin disease, possibly following the neurogenic skin inflammation model. Neurokinin B, involved in the pathogenesis of Parkinson’s disease, frequently coexisting with subsequent onset of rosacea, is an endogenous ligand of the tachykinin receptor 3 (TACR3). Methods. 128 rosacea patients and 121 matched controls were genotyped for rs3733631 by PCR-RFLP and analyzed by chi-square test. Results. We observed statistically significant predominance of the C/G or G/G genotype () and of the G allele () in the papulopustular (PP) form of rosacea and statistically marginal significance of the C/G or G/G genotype in erythematotelangiectatic (ET) rosacea (). Significantly higher frequency of the C/G or G/G genotype and G allele in PP rosacea ( and , resp.) was ascertained within male patients. Conclusion. TACR3 rs3733631 G allele possibly predisposes the evolution of the initial phase of rosacea to the PP and not the ET form in male patients.