International Scholarly Research Notices / 2015 / Article / Tab 1

Research Article

Toxicity Evaluation of Pũrṇa Cantirotaya Centũram, a Siddha Medicine in Wistar Rats

Table 1

Effect of Pũrṇa Cantirotaya Centũram on hematological parameters.

ParametersControl (honey)Low dose (2.5 mg/kg b.w.)Mid dose (25 mg/kg b.w.)High dose (50 mg/kg b.w.)

WBC (109/L)8.06 ± 5.065.26 ± 4.116.87 ± 4.687.48 ± 6.19
Lymph %62.13 ± 11.7261.89 ± 20.7156.05 ± 7.9960.22 ± 5.43
Mon  %4.30 ± 1.793.42 ± 1.38 3.66 ± 0.354.46 ± 1.52
Gran  %34.32 ± 9.7934.69 ± 19.4840.29 ± 7.9935.32 ± 3.97
RBC (1012/L)7.16 ± 3.585.29 ± 3.576.70 ± 3.067.76 ± 3.66
HGB (g/dL)12.11 ± 6.038.90 ± 6.0911.27 ± 5.7712.45 ± 5.84
HCT %35.02 ± 18.0626.36 ± 18.1731.00 ± 14.2437.33 ± 17.54
MCV (fL)51.66 ± 5.9949.97 ± 3.4248.52 ± 2.6949.07 ± 1.64
MCH (pg)17.82 ± 2.9016.68 ± 1.2616.38 ± 1.0516.27 ± 0.58
MCHC (g/dL)34.67 ± 2.6333.55 ± 1.5730.57 ± 10.7433.27 ± 0.57
RDW %13.05 ± 3.8111.44 ± 0.8911.650 ± 1.2311.43 ± 0.94
PLT (109/L)200.70 ± 78.19210.9 ± 55.6227.5 ± 55.95196.50 ± 144.17
MPV (fL)6.53 ± 0.626.76 ± 1.036.38 ± 0.766.50 ± 0.64
PDW15.30 ± 0.4715.74 ± 0.8915.45 ± 0.5515.130 ± 0.46
PCT %0.131 ± 0.040.130 ± 0.030.142 ± 0.0350.130 ± 0.10

Comparison was made between vehicle control and test groups using the one-way ANOVA test followed by Dunnett’s test. Values are mean ± SD for 10 rats in each group ( ≤ 0.05).
RBC: red blood corpuscles; HGB: hemoglobin; HCT: hematocrit; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; WBC: white blood cells; PLT: platelets; MPV: mean platelet volume; PCT: plateletcrit; RDW: red blood cell distribution width; PDW: platelet distribution width.