International Scholarly Research Notices / 2015 / Article / Tab 2

Research Article

Toxicity Evaluation of Pũrṇa Cantirotaya Centũram, a Siddha Medicine in Wistar Rats

Table 2

Effect of Pũrṇa Cantirotaya Centũram on biochemistry parameters.

ParametersControl (honey)Low dose (2.5 mg/kg b.w.)Mid dose (25 mg/kg b.w.)High dose (50 mg/kg b.w.)

Glucose (mg/dL)111.20 ± 21.0790.20 ± 27.9394.20 ± 29.65102.10 ± 38.30
Blood urea (mg/dL)34.90 ± 8.9746.60 ± 9.139.90 ± 8.9929.80 ± 6.4
Creatinine (mg%)0.73 ± 0.240.990 ± 0.30.92 ± 0.360.62 ± 0.12
Cholesterol (mg/dL)112.70 ± 38.86153.30 ± 45.3110.70 ± 42.0694.80 ± 17.88
TGL (mg/dL)89.00 ± 18.0887.10 ± 29.7775.80 ± 19.1187.40 ± 25.20
Total protein (g%)8.32 ± 0.568.38 ± 0.6410.24 ± 2.1710.15 ± 3.67
Albumin (g%)2.79 ± 0.353.04 ± 0.42.35 ± 0.452.98 ± 0.43
S. bilirubin (mg/dL)0.710 ± 0.1190.74 ± 0.060.630 ± 0.140.610 ± 0.21
SGOT (IU/L)168.00 ± 14.81165.50 ± 19.092167.80 ± 16.19169.10 ± 12.76
SGPT (IU/L)62.00 ± 8.9157.70 ± 14.85549.40 ± 8.0567.60 ± 41.21
(mEq/L)130.10 ± 5.56132.20 ± 2.300133.10 ± 1.66133.10 ± 2.02
(mEq/L)5.76 ± 2.436.26 ± 1.19095.590 ± 1.205.240 ± 0.72
(mEq/L)107.00 ± 1.41106.30 ± 1.947105.90 ± 1.79105.90 ± 1.79

Comparison was made between vehicle control and test groups using the one-way ANOVA test followed by Dunnett’s test. Values are mean ± SD for 10 rats in each group ( < 0.05).
TGL: triglycerides, SGOT: serum glutamic oxaloacetic transaminase, SGPT: serum glutamic pyruvic transaminase, : sodium, : potassium, and : chloride.