Table of Contents
International Scholarly Research Notices
Volume 2015, Article ID 790186, 10 pages
http://dx.doi.org/10.1155/2015/790186
Research Article

High Risk Stage 2 and Stage 3 Colon Cancer, Predictors of Recurrence and Effect of Adjuvant Therapy in a Nonselected Population

Department of Internal Medicine, Zaans Medisch Centrum, 1015 ZW Zaandam, Netherlands

Received 24 March 2015; Accepted 19 May 2015

Academic Editor: Marilena Loizidou

Copyright © 2015 Elmer E. van Eeghen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Patients with stage 2 and stage 3 colon cancer often are treated with adjuvant chemotherapy. However, patients seen in daily practice have more comorbidity than those enrolled in clinical trials. This study aims to evaluate prognostic factors for recurrence and to ascertain the benefit of adjuvant chemotherapy on recurrence-free survival (RFS) of patients in a nonselected population. Furthermore, the impact of relative dose intensity (RDI) of adjuvant therapy on RFS is examined. Chart review was performed for 243 consecutive patients diagnosed and treated at a single center for stage 2 and stage 3 colon cancer from 2002 to 2008. Adjuvant chemotherapy was administered to 66 patients. Median overall survival (OS) was 5.84 years and median RFS was 5.37 years. For stage 2 disease, patients treated with or without adjuvant therapy had a median RFS of 5.49 and 5.73, respectively ( = ns). For stage 3 disease, median RFS rates were 5.08 and 1.19, respectively (). Overall RDI of oxaliplatin based chemotherapy higher than median was associated with increased RFS (). In conclusion, adjuvant therapy did not significantly increase recurrence-free survival. This could be the result of comorbidity in patients. Relative dose intensity of oxaliplatin based therapy is associated with RFS.