Toxicity and Loss of Mitochondrial Membrane Potential Induced by Alkyl Gallates in Trypanosoma cruzi
Table 2
Synergism evaluation between hypothetical IC50 values used for calculation of FIC index.
Compound
IC50 (gallates alone)
IC50 (gallates with benznidazole)
FIC index
Interaction type
Gallic acid (01)
294a
17.4
2.017
I
Methyl gallate (02)
271a
15.3
1.786
I
Ethyl gallate (03)
252a
10.2
1.193
I
Propyl gallate (04)
235a
8.90
1.043
I
Butyl gallate (05)
221a
7.47
0.878
A
Pentyl gallate (06)
208a
6.02
0.708
A
Hexyl gallate (07)
196a
2.28
0.257
S
Heptyl gallate (08)
37.3
0.64
0.084
S
Octyl gallate (09)
6.49
0.62
0.165
S
Nonyl gallate (10)
0.86
0.44
0.560
A
Decyl gallate (11)
0.46
0.24
0.548
A
Undecyl gallate (12)
0.47
0.32
0.716
A
Dodecyl gallate (13)
0.72
0.51
0.765
A
Tetradecyl gallate (14)
6.44
0.58
0.155
S
Benznidazoleb
8.84
—
—
—
aHypothetical IC50 value used for calculating of FIC index.
bPositive control. I, A, and S mean indifferent interaction, antagonism, and synergism, respectively.