Table of Contents
International Scholarly Research Notices
Volume 2017 (2017), Article ID 6053267, 4 pages
https://doi.org/10.1155/2017/6053267
Research Article

Frequency of Neurological Disorders in Bullous Pemphigoid Patients: A Cross-Sectional Study

1Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
2Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Dermatology Department, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Comprehensive Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA

Correspondence should be addressed to Nasrin Saki

Received 5 April 2017; Accepted 4 May 2017; Published 24 May 2017

Academic Editor: Mauro Alaibac

Copyright © 2017 Sheida Khosravani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Bullous pemphigoid (BP) is an autoimmune subepidermal blistering skin disorder which occurs mostly in the elderly. Several studies have reported an association between BP and neurological disorders (ND). Objective. The purpose of this study was to evaluate the association between BP and neurological disorders in Iranian patients. Methods. In this cross-sectional study, 87 patients with BP were enrolled. They were compared to 184 controls. Statistical analysis was done by SPSS statistical software version 19. Results. Out of 87 patients with BP, 17 (19.5%) had at least one neurological disease. Cerebrovascular accident (CVA) was the most common neurological disease that was seen in 7 patients (8.0%) in the case group and 4 (2.1%) in the control group. The incidence of CVA was significantly different between BP patients and the control group (). Dementia was observed in 6 patients in the case group (16.8%) and 2 (1.0%) in the control group. The incidence of dementia was significantly different between BP patients and the control group (). In this study, the incidences of Parkinson’s disease (), epilepsy (), and multiple sclerosis () were not statistically significant between the two groups. Conclusion. The incidence of CVA and dementia in patients with BP compared to the control group was significantly higher.