Table of Contents
Journal of Allergy
Volume 2009, Article ID 518903, 6 pages
Clinical Study

Conjunctivitis and Total IgE in Lacrimal Fluid: Lacrytest Screening

1Allergy Department, Dexeus Institute, Universitat Autònoma de Barcelona (UAB), 08028 Barcelona, Spain
2Ophthalmology Department, Mutua de Terrassa Hospital, 08221 Barcelona, Spain
3Laboratori de Bioestadística i Epidemiología (LBE), Universitat Autònoma de Barcelona (UAB), 08193 Barcelona, Spain
4Servei de Farmacologia Clínica, Unitat d'Avaluació Prevenció i Suport (UASP), Hospital Clínic, 08036 Barcelona, Spain

Received 29 December 2008; Accepted 9 March 2009

Academic Editor: Nima Rezaei

Copyright © 2009 Susana Monzón et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Total tear IgE has been considered to play an important role in allergic conjunctivitis, and measurement has been considered useful for diagnosis. The aim of this study was to ascertain whether Lacrytest®, a new commercialised method to detect IgE levels in lacrimal fluid, could constitute a screening test for the diagnosis of allergic conjunctivitis. This was a cross-sectional study. Patients with seasonal and perennial allergic conjunctivitis, vernal keratoconjunctivitis and a control group were included. Clinical history, ophthalmic examination, skin prick test and conjunctival provocation test were obtained. Lacrytest® was later performed in all groups. Fifty-four patients were enrolled: thirty with IgE-mediated conjunctivitis and, nine with vernal keratoconjunctivitis and fifteen controls. Lacrytest® was negative in all controls, positive in 20% of the IgE-mediated conjunctivitis group and in 88.9% of the vernal keratoconjunctivitis group. Global statistically-significant differences were found among the three groups ( 𝑃 = . 0 0 3 ). Sensitivity of the test in the IgE-mediated conjunctivitis group was 20%, specificity 100%, positive predictive value 100%, and negative predictive value 38.46%, while in VKC sensitivity was 88.88%, specificity 100%, positive predictive value 100%, and negative predictive value 93.75%. Our data confirm that this test is not useful for screening allergic conjunctivitis. Lacrytest®, while not providing any useful information to an allergist, could be helpful for ophthalmologists to confirm an IgE-mediated or VKC conjunctivitis.