Table of Contents
Journal of Allergy
Volume 2011, Article ID 479129, 4 pages
Case Report

A Case of Severe Bronchial Asthma Controlled with Tacrolimus

1The Department of Internal Medicine, Toyama Prefectural Central Hospital, 2-2-78 Nishinage, Toyama 930-8550, Japan
2The Department of Radioloy, Toyama Prefectural Central Hospital, 2-2-78 Nishinage, Toyama 930-8550, Japan

Received 6 December 2010; Accepted 7 February 2011

Academic Editor: Redwan Moqbel

Copyright © 2011 Hirokazu Taniguchi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The control of severe bronchial asthma, such as corticosteroid-resistant asthma, is difficult. It is also possible that immunosuppressive agents would be effective for bronchial asthma. Case Summary. A 55-year-old Japanese female presented with severe bronchial asthma controlled with tacrolimus. She had been diagnosed with bronchial asthma during childhood. Her asthma worsened, and a chest radiograph showed atelectasis of the left lung. Bronchoscopy revealed the left main bronchus to be obstructed with viscous sputum consisting of 82% neutrophils and no eosinophils. The atelectasis did not improve with corticosteroid treatment, but was ameliorated by administration of tacrolimus. Discussion. This patient had severe asthma due to neutrophilic inflammation of the airways. Tacrolimus is effective for treating severe asthma, for example, in corticosteroid-resistant cases.