Review Article
Lung Dendritic Cell Developmental Programming, Environmental Stimuli, and Asthma in Early Periods of Life
Table 1
DC subsets in patients with asthma.
| Clinical Condition | Altered DC phenotypes | References |
| Asthma | pDC (HLA-DR+, CD123+) increased in BALF mDC (HLA-DR+, CD11c+) increased in BALF | [99] | Allergic asthma | mDC (BDCA-3+, mannose receptor+) increased in BALF | [100] | Allergic asthma | pDC (BDCA4+) with increased FcεRI in blood mDC (CD1c+) with increased FcεRI in blood | [101, 102] | Asthma | Increased DC proportions in peripheral blood | [103] | Allergic asthma patients challenged with allergen | Increased pDC and mDC in sputum | [104] | Asthma | Increase in pDC1 and pDC2 expressing FcεRI | [105] | Repeated exposure to allergen | Depletion of mDCs | [23] | Asthmatic children | DC2 (CD11c−, CD123high+) decreased in blood | [106] | Asthmatic patients | Increased CD1a+ cells in bronchial mucosa | [107] | Experimentally elicited allergic rhinitis | pDC increased in nasal mucosa | [108] | Asthma | pDC increased; decreased mDC : pDC ratio in blood | [109] | Children with asthma | Deficiency of circulating pDC | [110] | Atopic patients with chronic rhinosinusitis | Increased FcεRI on DC (CD1+) | [111] |
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Abbreviations: BALF: bronchoalveolar lavage fluid, mDC: myeloid DC, pDC: plasmacytoid DC, BDCA: blood dendritic cell antigen.
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