Journal of Allergy / 2012 / Article / Tab 2

Review Article

Interleukin-4 in the Generation of the AERD Phenotype: Implications for Molecular Mechanisms Driving Therapeutic Benefit of Aspirin Desensitization

Table 2

PgE2 metabolic pathway gene expression in control and AERD tissue.

GeneControl AERD ( )2

COX-1 −0.8 (.57)
COX-2 * −1.9 (.27)
mPGES-1 −1 (.5)
mPGES-2 * −1.7 (.31)
cPGES +0.1 (1.07)

* .
1Quantitiatve polymerase chain reaction data are presented as , which is the difference in threshold cycle of expression of each gene compared to housekeeping gene (each cycle corresponds to ~1 log2 difference in mRNA concentration; a higher represents less mRNA).
2 is the difference in of gene expressed in control compared to AERD tissue.
is the relative expression of gene in AERD compared to control tissue.

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