Integrin and GPCR Crosstalk in the Regulation of ASM Contraction Signaling in Asthma

Table 2

Expression of ECM proteins/integrin ligands, their potential crosstalk with G proteins and change in expression in disease.

ECM/integrin ligands	Potential crosstalk with G proteins	Disease	Reference
Cyr61	G12/13	↑ in breast and endometrial cancers	[44]
RGD sequence in P2Y2 receptor	G0	n.d.	[45]
Laminin-111	Gi, and Gs	↑ in asthma	[46–48]
Fibronectin	Gq and G12/13	↑ in asthma	[47–50]
Collagen I	Gq	↑ in asthma	[47, 48, 51]
Collagen V	Gi and Gs	↑ in asthma	[46–48]

n.d.: not determined.