Table of Contents
Journal of Allergy
Volume 2012, Article ID 681258, 9 pages
Review Article

Cholinergic Regulation of Airway Inflammation and Remodelling

1Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Iran
2Department of Molecular Pharmacology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands

Received 21 June 2011; Accepted 10 October 2011

Academic Editor: Irene Heijink

Copyright © 2012 Saeed Kolahian and Reinoud Gosens. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Acetylcholine is the predominant parasympathetic neurotransmitter in the airways that regulates bronchoconstriction and mucus secretion. Recent findings suggest that acetylcholine regulates additional functions in the airways, including inflammation and remodelling during inflammatory airway diseases. Moreover, it has become apparent that acetylcholine is synthesized by nonneuronal cells and tissues, including inflammatory cells and structural cells. In this paper, we will discuss the regulatory role of acetylcholine in inflammation and remodelling in which we will focus on the role of the airway smooth muscle cell as a target cell for acetylcholine that modulates inflammation and remodelling during respiratory diseases such as asthma and COPD.