Figure 1: Overall effects of IL-22, TNFα, IL-4, and IL-13 combination (AD) or IL-22, TNFα, and IL-17 combination (PSO) on the transcriptome of keratinocytes in monolayer culture (NHEK). NHEKs were cultured in duplicate cultures with 10 ng/mL of each cytokines for 24 h and the gene expression profiles were analysed using Affymetrix hU219 chips. The number of significantly modulated (±2-fold the control) genes is indicated for each treatment (average of duplicate analysis) as well as the number of genes modulated by the two treatments.