Aspirin Sensitivity and Chronic Rhinosinusitis with Polyps: A Fatal Combination

Table 1

Organ manifestation of symptoms in AERD. The classification of AERD is based on the clinical picture and becomes obvious in diverse organs at different times in the course until all symptoms of AERD will have been developed. Accurately timed diagnosis of AERD is a major challenge in patients suffering from CRS with as well as without nasal polyps and/or bronchial asthma. But also individuals without known underlying airway-related diseases have to be considered as aspirin sensitive. Thoroughly taken medical history and scrutinising the patient’s organ manifestation remain a fundamental challenge. Some of the most prominent symptoms associated with AERD are summarised (without the claim of being complete) for the identification of early indicators of AERD.

Organ manifestation	Symptoms
	(i) Rhinosinusitis without nasal polyps
	(ii) Rhinosinusitis with nasal polyps
Airways	(iii) Dyspnoea
	(iv) Bronchial asthma
	(v) Laryngeal oedema
Skin	(i) Urticaria
	(ii) Angioedema
	(i) Vomiting
	(ii) Diarrhoea
Gastrointestinal tract	(iii) Dyspepsia
	(iv) Gastric bleeding
	(v) Peptic ulcer disease
	(vi) Intestinal  ulcer
	(i) Cardiovascular diseases
Other organs	(ii) Anaphylaxis
	(iii) Sepsis
	(iv) Tinnitus